Epigenetic Mechanisms of LncRNAs Binding to Protein in Carcinogenesis.
Epigenetic Mechanisms of LncRNAs Binding to Protein in Carcinogenesis.
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DOI：
10.3390/cancers12102925
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发表时间：
2020-10-11
期刊：
影响因子：
5.2
通讯作者：
Cho JY
中科院分区：
文献类型：
--
作者：
Shin TJ;Lee KH;Cho JY
lncRNA的功能分析，最近已在生物学研究的各个领域进行了研究，对于理解细胞的微妙控制和疾病的发生至关重要。蛋白质与lncRNA之间的相互作用是肿瘤发生、发展的主要机制之一。本文对从肿瘤发生、转移到化疗耐药过程中的lncRNA及其相关蛋白进行了综述，以期更好地了解肿瘤，并进一步开发新的治疗方法，为临床肿瘤的诊断、预后和治疗提供新的视角。表观遗传失调是癌症发生和发展的重要特征。长链非编码RNA（lncRNA）是以RNA形式稳定存在的转录物，其长度大于200个核苷酸，没有翻译蛋白。LncRNA可以表观遗传地调节癌基因或肿瘤抑制基因。目前，lncRNA与蛋白质分析相结合的研究越来越受到重视。LncRNA通过与靶基因的转录因子结合来直接控制基因表达，并通过与其他蛋白质复合以与靶蛋白质结合并引起蛋白质降解、降低蛋白质稳定性或干扰其他蛋白质的结合来间接控制基因表达。各种研究表明，lncRNA通过调节表观遗传基因而促进癌症发展，并且已经进行了研究以确定哪些蛋白质与lncRNA结合并促进癌症发展。在这篇综述中，我们深入研究了lncRNA的表观遗传调控功能，这些lncRNA能够与癌症发展中的其他蛋白质复合。
The functional analysis of lncRNA, which has recently been investigated in various fields of biological research, is critical to understanding the delicate control of cells and the occurrence of diseases. The interaction between proteins and lncRNA, which has been found to be a major mechanism, has been reported to play an important role in cancer development and progress. This review thus organized the lncRNAs and related proteins involved in the cancer process, from carcinogenesis to metastasis and resistance to chemotherapy, to better understand cancer and to further develop new treatments for it. This will provide a new perspective on clinical cancer diagnosis, prognosis, and treatment. Epigenetic dysregulation is an important feature for cancer initiation and progression. Long non-coding RNAs (lncRNAs) are transcripts that stably present as RNA forms with no translated protein and have lengths larger than 200 nucleotides. LncRNA can epigenetically regulate either oncogenes or tumor suppressor genes. Nowadays, the combined research of lncRNA plus protein analysis is gaining more attention. LncRNA controls gene expression directly by binding to transcription factors of target genes and indirectly by complexing with other proteins to bind to target proteins and cause protein degradation, reduced protein stability, or interference with the binding of other proteins. Various studies have indicated that lncRNA contributes to cancer development by modulating genes epigenetically and studies have been done to determine which proteins are combined with lncRNA and contribute to cancer development. In this review, we look in depth at the epigenetic regulatory function of lncRNAs that are capable of complexing with other proteins in cancer development.
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影响因子：
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作者：
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