Potassium homeostasis: sensors, mediators, and targets.
Potassium homeostasis: sensors, mediators, and targets.
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DOI：
10.1007/s00424-022-02718-3
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发表时间：
2022-08
影响因子：
4.5
通讯作者：
Fenton, Robert A.
中科院分区：
文献类型：
--
作者：
McDonough, Alicia A.;Fenton, Robert A.
关键词：
跨膜钾（K）梯度是膜电位的关键决定因素，可以调节动作电位，控制肌肉收缩性，并影响离子通道和转运蛋白活性。每日K摄入量通常等于整个细胞外液（ECF）中的K量，这产生了一个关键挑战-如何在盛宴和饥饿期间将ECF [K]和膜电位维持在窄范围内。维持ECF [K]的适应包括感测K摄入，感测ECF [K]与期望的设定点，并激活调节ECF和ICF之间的K分布的介质，以及调节肾K排泄。在这篇集中的综述中，我们讨论了这些适应的基础，包括（1）餐后（ECF [K]上升之前）快速前馈信号传递到肾脏和肌肉的潜在机制，（2）骨骼肌如何感知和响应ECF [K]的变化，（3）K对醛固酮生物合成的影响，以及（4）肾脏如何响应ECF [K]的变化以改变K的排泄。介绍了肾脏钾处理适应性的两性异形的概念，并讨论了富含钾的饮食对维持心血管健康的益处的分子机制。虽然K稳态的大局变得越来越清晰，但我们也强调了仍有待解决的重要难题，包括我们对启动信号，传感器及其与ECF [K]稳态调节的联系的理解中的知识差距。
Transmembrane potassium (K) gradients are key determinants of membrane potential that can modulate action potentials, control muscle contractility, and influence ion channel and transporter activity. Daily K intake is normally equal to the amount of K in the entire extracellular fluid (ECF) creating a critical challenge — how to maintain ECF [K] and membrane potential in a narrow range during feast and famine. Adaptations to maintain ECF [K] include sensing the K intake, sensing ECF [K] vs. desired set-point and activating mediators that regulate K distribution between ECF and ICF, and regulate renal K excretion. In this focused review, we discuss the basis of these adaptions, including (1) potential mechanisms for rapid feedforward signaling to kidney and muscle after a meal (before a rise in ECF [K]), (2) how skeletal muscles sense and respond to changes in ECF [K], (3) effects of K on aldosterone biosynthesis, and (4) how the kidney responds to changes in ECF [K] to modify K excretion. The concepts of sexual dimorphisms in renal K handling adaptation are introduced, and the molecular mechanisms that can account for the benefits of a K-rich diet to maintain cardiovascular health are discussed. Although the big picture of K homeostasis is becoming more clear, we also highlight significant pieces of the puzzle that remain to be solved, including knowledge gaps in our understanding of initiating signals, sensors and their connection to homeostatic adjustments of ECF [K].
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DOI：
10.1007/s00424-014-1628-6
发表时间：
2015-05
期刊：
Pflugers Archiv : European journal of physiology
影响因子：
--
作者：
Bandulik S;Tauber P;Lalli E;Barhanin J;Warth R
通讯作者：
Warth R
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影响因子：
3.3
作者：
Boyd-Shiwarski CR;Shiwarski DJ;Roy A;Namboodiri HN;Nkashama LJ;Xie J;McClain KL;Marciszyn A;Kleyman TR;Tan RJ;Stolz DB;Puthenveedu MA;Huang CL;Subramanya AR
通讯作者：
Subramanya AR
DOI：
10.1073/pnas.1817220116
发表时间：
2019-03-05
影响因子：
11.1
作者：
Chen, Jen-Chi;Lo, Yi-Fen;Cheng, Chih-Jen
通讯作者：
Cheng, Chih-Jen
影响因子：
4.5
作者：
Czogalla, Jan;Vohra, Twinkle;Loffing, Johannes
通讯作者：
Loffing, Johannes
影响因子：
64.8
作者：
Boyden, Lynn M.;Choi, Murim;Choate, Keith A.;Nelson-Williams, Carol J.;Farhi, Anita;Toka, Hakan R.;Tikhonova, Irina R.;Bjornson, Robert;Mane, Shrikant M.;Colussi, Giacomo;Lebel, Marcel;Gordon, Richard D.;Semmekrot, Ben A.;Poujol, Alain;Valimaki, Matti J.;De Ferrari, Maria E.;Sanjad, Sami A.;Gutkin, Michael;Karet, Fiona E.;Tucci, Joseph R.;Stockigt, Jim R.;Keppler-Noreuil, Kim M.;Porter, Craig C.;Anand, Sudhir K.;Whiteford, Margo L.;Davis, Ira D.;Dewar, Stephanie B.;Bettinelli, Alberto;Fadrowski, Jeffrey J.;Belsha, Craig W.;Hunley, Tracy E.;Nelson, Raoul D.;Trachtman, Howard;Cole, Trevor R. P.;Pinsk, Maury;Bockenhauer, Detlef;Shenoy, Mohan;Vaidyanathan, Priya;Foreman, John W.;Rasoulpour, Majid;Thameem, Farook;Al-Shahrouri, Hania Z.;Radhakrishnan, Jai;Gharavi, Ali G.;Goilav, Beatrice;Lifton, Richard P.
通讯作者：
Lifton, Richard P.