Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy.
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy.
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DOI：
10.1038/nri3552
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发表时间：
2013-12
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脓毒症-严重威胁生命的感染并伴有器官功能障碍-启动了宿主促炎和抗炎过程的复杂相互作用。在真正意义上，败血症可以被认为是病原体和宿主免疫系统之间的一场死亡竞赛。正是在经常相互竞争的促炎和抗炎途径之间取得适当的平衡，才能决定个人的命运。尽管脓毒症的研究领域见证了许多备受推崇的临床试验的失败，但更好地了解这种疾病的病理生理学基础以及相关的促炎和抗炎反应的机制正在导致一种治疗这种高度致命疾病的新方法。在脓毒症的适当免疫阶段对患者进行生物标记物引导的免疫治疗，代表着脓毒症治疗以及更广泛的传染病领域的潜在重大进展。
Sepsis — severe life-threatening infection with organ dysfunction — initiates a complex interplay of host pro- and anti-inflammatory processes. In a real sense, sepsis can be considered a race to the death between the pathogens and the host immune system. It is the proper balance between the often competing pro- and anti-inflammatory pathways that determines the fate of the individual. Although the field of sepsis research has witnessed the failure of many highly-touted clinical trials, a better understanding of the pathophysiological basis of the disorder and the mechanisms responsible for the associated pro- and anti-inflammatory responses is leading to a novel approach to treat this highly lethal condition. Biomarker-guided immunotherapy administered to patients at the proper immune phase of sepsis represents a potential major advance in the treatment of sepsis and more broadly in the field of infectious disease.
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DOI：
10.1186/cc5055
发表时间：
2006
期刊：
Critical care (London, England)
影响因子：
--
作者：
Cavaillon JM;Adib-Conquy M
通讯作者：
Adib-Conquy M
影响因子：
120.7
作者：
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通讯作者：
Hotchkiss, Richard S.
DOI：
10.1186/cc12711
发表时间：
2013-05-11
期刊：
Critical care (London, England)
影响因子：
--
作者：
Chang KC;Burnham CA;Compton SM;Rasche DP;Mazuski RJ;McDonough JS;Unsinger J;Korman AJ;Green JM;Hotchkiss RS
通讯作者：
Hotchkiss RS
影响因子：
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作者：
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通讯作者：
Hotchkiss, Richard S.
影响因子：
6
作者：
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通讯作者：
Kunkel, SL