Dimensional correlates of poor insight in obsessive-compulsive disorder.
Dimensional correlates of poor insight in obsessive-compulsive disorder.
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DOI：
10.1016/j.pnpbp.2011.05.012
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发表时间：
2011-08-15
影响因子：
5.6
通讯作者：
Bloch, Michael H.
中科院分区：
文献类型：
--
作者：
Jakubovski, Ewgeni;Pittenger, Christopher;Torres, Albina Rodrigues;Fontenelle, Leonardo Franklin;do Rosario, Maria Conceicao;Ferroo, Ygor Arzeno;de Mathis, Maria Alice;Miguel, Euripedes Constantino;Bloch, Michael H.
横断面研究表明，强迫症(OCD)患者的自知力较差，强迫症症状严重程度增加，合并抑郁症的年龄较早，治疗反应也较差。这项研究的目的是在一大批巴西强迫症患者的临床队列中检查强迫症症状和自知力的维度之间的关系。我们预计自知力差与总症状严重程度以及囤积症状严重程度有关。对824例门诊强迫症患者进行了详细的临床评估，包括耶鲁-布朗强迫量表(Y-BOCS)、维度耶鲁-布朗强迫量表(D-YBOCS)、布朗信念评定量表(BABS)、社会人口学问卷和轴心I-DSM-IV障碍的结构化临床访谈(SCID-P)。托比特回归模型被用来检验自知力水平和感兴趣的临床变量之间的关联。在控制了目前的强迫症严重程度、年龄和性别后，目前和有史以来最严重的囤积症状的严重程度与强迫症的洞察力较差有关。自知力差也与目前强迫症症状严重程度的增加有关。所解释的囤积症和总体强迫症严重程度与强迫症患者的自知力水平显著相关，但相关性较弱。进一步的研究应该在行为疗法和药理学试验中检验洞察力作为强迫症治疗反应的调节和中介。旨在提高洞察力的行为技术可能对强迫症有潜在的好处，特别是在有囤积症的患者中。
Cross-sectional studies have associated poor insight in patients with obsessive-compulsive disorder (OCD) with increased OCD symptom severity, earlier age of comorbid depression, and treatment response. The goal of this current study was to examine the relationship between dimensions of OCD symp tomatology and insight in a large clinical cohort of Brazilian patients with OCD. We expect poor insight to be associated with total symptom severity as well as with hoarding symptoms severity. 824 outpatients underwent a detailed clinical assessment for OCD, including the Yale–Brown Obsessive–Compulsive Scale (Y-BOCS), the Dimensional Yale–Brown Obsessive–Compulsive Scale (D-YBOCS), the Brown Assessment of Beliefs Scale (BABS), a socio-demographic questionnaire, and the Stuctured Clinical Interview for axis I DSM-IV disorders (SCID-P). Tobit regression models were used to examine the association between level of insight and clinical variables of interest. Increased severity of current and worst-ever hoarding symptoms was associated with poor insight in OCD after controlling for current OCD severity, age and gender. Poor insight was also correlated with increased current OCD symptom severity. Hoarding and overall OCD severity explained were significantly but weakly associated with level of insight in OCD patients. Further studies should examine insight as a moderator and mediator of treatment response in OCD in both behavioral therapy and pharmacological trials. Behavioral techniques aimed at enhancing insight may be potentially beneficial in OCD, especially among patients with hoarding.
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DOI：
10.1176/appi.ajp.2008.08020320
发表时间：
2008-12
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Bloch MH;Landeros-Weisenberger A;Rosario MC;Pittenger C;Leckman JF
通讯作者：
Leckman JF
影响因子：
22.8
作者：
Mataix-Cols, D;Marks, IM;Baer, L
通讯作者：
Baer, L
影响因子：
--
作者：
Mataix-Cols, D;Wooderson, S;Phillips, ML
通讯作者：
Phillips, ML
影响因子：
7.3
作者：
Eisen, JL;Rasmussen, SA;Piggott, T
通讯作者：
Piggott, T
影响因子：
7.8
作者：
Marazziti, D;Dell'Osso, L;Cassano, GB
通讯作者：
Cassano, GB