Novel multimorbidity clusters in people with eczema and asthma: a population-based cluster analysis.
Novel multimorbidity clusters in people with eczema and asthma: a population-based cluster analysis.
复制标题
DOI：
10.1038/s41598-022-26357-x
复制
发表时间：
2022-12-18
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
湿疹和哮喘是过敏性疾病，也是高收入国家最常见的两种慢性病。它们与其他过敏性疾病共存是很常见的，但很少有关于这些疾病更广泛的多发病的研究。我们着手识别并比较患有湿疹或哮喘的人和没有湿疹或哮喘的人的多发病群。使用从英国临床研究实践 Datalink GOLD 定期收集的初级保健数据，我们确定了曾经患有湿疹（或哮喘）的成年人，以及从未患有湿疹（或哮喘）的对照组。我们通过对混合效应逻辑回归估计的诊断类别对之间的杰卡德距离进行层次聚类分析，得出了多发病聚类。我们分析了 434,422 名湿疹患者（58% 女性，中位年龄 47 岁）和 1,333,281 名无湿疹患者（55% 女性，47 岁），以及 517,712 名哮喘患者（53% 女性，44 岁）和 1,601,210 名无哮喘患者（53% 女性，45 岁）。首次发病年龄、性别和患有湿疹/哮喘会影响多重发病的范围，其中女性、老年和湿疹/哮喘与较大的发病群相关。湿疹和哮喘中的损伤、消化系统、神经系统和精神健康障碍比对照组更常见。所有年龄段和性别的患有湿疹和哮喘的人可能比没有湿疹和哮喘的人经历更高的多重发病率，包括以前未被认为会导致其疾病负担的疾病。这项工作强调了迫切需要研究解决多种疾病的负担和驱动因素的领域，以便为减少不良健康结果的策略提供信息。
Eczema and asthma are allergic diseases and two of the commonest chronic conditions in high-income countries. Their co-existence with other allergic conditions is common, but little research exists on wider multimorbidity with these conditions. We set out to identify and compare clusters of multimorbidity in people with eczema or asthma and people without. Using routinely-collected primary care data from the U.K. Clinical Research Practice Datalink GOLD, we identified adults ever having eczema (or asthma), and comparison groups never having eczema (or asthma). We derived clusters of multimorbidity from hierarchical cluster analysis of Jaccard distances between pairs of diagnostic categories estimated from mixed-effects logistic regressions. We analysed 434,422 individuals with eczema (58% female, median age 47 years) and 1,333,281 individuals without (55% female, 47 years), and 517,712 individuals with asthma (53% female, 44 years) and 1,601,210 individuals without (53% female, 45 years). Age at first morbidity, sex and having eczema/asthma affected the scope of multimorbidity, with women, older age and eczema/asthma being associated with larger morbidity clusters. Injuries, digestive, nervous system and mental health disorders were more commonly seen in eczema and asthma than control clusters. People with eczema and asthma of all ages and both sexes may experience greater multimorbidity than people without eczema and asthma, including conditions not previously recognised as contributing to their disease burden. This work highlights areas where there is a critical need for research addressing the burden and drivers of multimorbidity in order to inform strategies to reduce poor health outcomes.
登录
查看更多内容
DOI：
10.1016/j.lanepe.2021.100047
发表时间：
2021-04
期刊：
The Lancet regional health. Europe
影响因子：
--
作者：
Bisquera A;Gulliford M;Dodhia H;Ledwaba-Chapman L;Durbaba S;Soley-Bori M;Fox-Rushby J;Ashworth M;Wang Y
通讯作者：
Wang Y
影响因子：
3.7
作者：
Aguilar D;Pinart M;Koppelman GH;Saeys Y;Nawijn MC;Postma DS;Akdis M;Auffray C;Ballereau S;Benet M;García-Aymerich J;González JR;Guerra S;Keil T;Kogevinas M;Lambrecht B;Lemonnier N;Melen E;Sunyer J;Valenta R;Valverde S;Wickman M;Bousquet J;Oliva B;Antó JM
通讯作者：
Antó JM
影响因子：
4.4
作者：
Bougas, Nicolas;Just, Jocelyne;Momas, Isabelle
通讯作者：
Momas, Isabelle
影响因子：
6.5
作者：
Abuabara, Katrina;Magyari, Alexa M.;Langan, Sinead M.
通讯作者：
Langan, Sinead M.
影响因子：
2.8
作者：
Ha, Eun Kyo;Baek, Ji Hyeon;Han, Man Yong
通讯作者：
Han, Man Yong