Enthesitis-related arthritis is associated with higher pain intensity and poorer health status in comparison with other categories of juvenile idiopathic arthritis: the Childhood Arthritis and Rheumatology Research Alliance Registry.
Enthesitis-related arthritis is associated with higher pain intensity and poorer health status in comparison with other categories of juvenile idiopathic arthritis: the Childhood Arthritis and Rheumatology Research Alliance Registry.
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DOI：
10.3899/jrheum.120642
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
CARRA Registry Investigators
中科院分区：
文献类型：
--
作者：
Weiss PF;Beukelman T;Schanberg LE;Kimura Y;Colbert RA;CARRA Registry Investigators
目的：评估临床因素和药物对青少年特发性关节炎(JIA)疼痛强度、身体功能和健康状况的相对影响。我们对儿童关节炎和风湿病研究联盟(CARA)登记的JIA儿童的数据进行了一项回顾性横断面研究。我们使用多变量线性和有序Logistic回归来检验JIA的临床特征是否与疼痛强度、身体功能和健康状况有关。在研究期间，2,571名JIA受试者在CARA登记处登记。疼痛强度、身体功能和健康状况的评级在JIA类别之间存在显著差异。与其他类别的JIA相比，与终端炎相关关节炎(ERA)的受试者报告的疼痛和功能更差。在多变量分析中，较高的活跃关节数，以及目前非甾体抗炎药、生物或皮质类固醇的使用与患者报告的所有测量中的较差分数相关。年龄和年龄与较高的疼痛强度和较差的健康状况显著相关。系统性JIA和葡萄膜炎与较差的健康状况显著相关。终端炎、骶骨压痛和非甾体抗炎药的使用与ERA中疼痛强度的增加独立相关。医生对疾病活动的总体评估与患者报告的疼痛强度、身体功能和健康状况之间的相关性很低。疼痛强度、身体功能和健康状况在JIA类别之间存在显著差异。这些结果表明，目前的治疗方法对于在特定JIA类别中更常见的特定疾病特征可能不是同样有效，例如ERA中的终端炎或骶骨压痛。
To assess the relative impact of clinical factors and medications on pain intensity, physical function, and health status in juvenile idiopathic arthritis (JIA). We conducted a retrospective cross-sectional study of data from children with JIA enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. We tested whether clinical characteristics of JIA were associated with pain intensity, physical function, and health status using multivariable linear and ordinal logistic regression. During the study period, 2,571 JIA subjects enrolled in the CARRA Registry. Ratings of pain intensity, physical function, and health status differed significantly between JIA categories. In comparison to other categories of JIA, subjects with enthesitis-related arthritis (ERA) reported worse pain and function. In multivariable analyses, higher active joint count, and current NSAID, biologic, or corticosteroid use were associated with worse scores on all patient-reported measures. ERA and older age were significantly associated with higher pain intensity and poorer health status. Systemic JIA and uveitis were significantly associated with worse health status. Enthesitis, sacroiliac tenderness, and NSAID use were independently associated with increased pain intensity in ERA. The correlation between physician global assessment of disease activity and patient-reported pain intensity, physical function, and health status was low. Significant differences of pain intensity, physical function, and health status exist among JIA categories. These results suggest that current treatments may not be equally effective for particular disease characteristics more common in specific JIA categories, such as enthesitis or sacroiliac tenderness in ERA.
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影响因子：
5.5
作者：
Gutierrez-Suarez, R.;Pistorio, A.;Ruperto, N.
通讯作者：
Ruperto, N.
影响因子：
3.8
作者：
Norrby, U;Nordholm, L;Fasth, A
通讯作者：
Fasth, A
DOI：
10.1002/art.20529
发表时间：
2004-08-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Pouchot, J;Ecosse, E;Guillemin, F
通讯作者：
Guillemin, F
影响因子：
5.5
作者：
Ding, T.;Hall, A.;David, J.
通讯作者：
David, J.
影响因子：
7.4
作者：
PRICE, DD;BUSH, FM;HARKINS, SW
通讯作者：
HARKINS, SW