A population-based cohort study on the risk of obstructive lung disease after bilateral oophorectomy.
A population-based cohort study on the risk of obstructive lung disease after bilateral oophorectomy.
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DOI：
10.1038/s41533-022-00317-4
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发表时间：
2022-11-15
影响因子：
3.1
通讯作者：
Scrodin, Megan M. Dulohery
中科院分区：
文献类型：
--
作者：
Nguyen, Trinh T.;Smith, Carin Y.;Rocca, Liliana Gazzuola;Rocca, Walter A.;Vassallo, Robert;Scrodin, Megan M. Dulohery
越来越多的证据表明性激素可能影响阻塞性肺病（OLD）的发展。因此，我们研究双侧卵巢切除术（oophorectomy）对OLD发展的影响。这些女性是从梅奥诊所卵巢切除术和衰老队列研究中确定的。使用罗切斯特流行病学项目记录链接系统收集数据。采用诊断代码和病历提取对1653名接受过卵巢切除术的妇女和1653名年龄相仿的参考妇女进行了OLD评估。接受卵巢切除术的女性患老年痴呆症、慢性阻塞性肺疾病（COPD）、肺气肿和慢性支气管炎的风险总体较高，但哮喘、确诊哮喘或确诊COPD的风险并不高。在进行卵巢切除术时年龄≤45岁、从不吸烟、非肥胖和有良性适应症的女性中，与所有老年痴呆的相关性更强；然而，交互作用在统计上不显著。接受卵巢切除术的年龄≤45岁的妇女接受雌激素治疗，所有哮喘的风险增加。所有年龄段从不吸烟者的卵巢切除术与所有哮喘和所有COPD的相关性更强，而吸烟者的卵巢切除术与肺气肿和慢性支气管炎的相关性更强。所有年龄段非肥胖女性的卵巢切除术与所有COPD、肺气肿和慢性支气管炎的相关性更强。这项研究的结果结合先前研究中报道的几种慢性疾病的风险增加，建议绝经前妇女应避免卵巢切除术，除非有明确的证据表明卵巢癌的遗传风险很高。
There is increasing evidence that sex hormones may impact the development of obstructive lung disease (OLD). Therefore, we studied the effect of bilateral oophorectomy (oophorectomy) on the development of OLD. Women were identified from the Mayo Clinic Cohort Study of Oophorectomy and Aging-2. Data were collected using the Rochester Epidemiology Project records-linkage system. A total of 1653 women who underwent oophorectomy and 1653 referent women of similar age were assessed for OLD using diagnostic codes and medical record abstraction. Women who underwent oophorectomy had an overall higher risk of all OLD, all chronic obstructive pulmonary disease (COPD), emphysema, and chronic bronchitis but not of all asthma, confirmed asthma, or confirmed COPD. The association with all OLD was stronger in women who were age ≤45 years at oophorectomy, never smokers, non-obese, and in women with benign indications; however, the interactions were not statistically significant. There was an increased risk of all asthma in women age ≤45 years at oophorectomy who took estrogen therapy. Never smokers of all ages had a stronger association of oophorectomy with all asthma and all COPD, whereas smokers had a stronger association of oophorectomy with emphysema and chronic bronchitis. Non-obese women of all ages had a stronger association of oophorectomy with all COPD, emphysema, and chronic bronchitis. The results of this study combined with the increased risk of several chronic diseases reported in previous studies suggest that oophorectomy in premenopausal women should be avoided unless there is clear evidence of a high genetic risk of ovarian cancer.
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影响因子：
--
作者：
Barr, RG;Wentowski, CC;Camargo, CA
通讯作者：
Camargo, CA
影响因子：
9.6
作者：
Rao, Chitra K.;Moore, Charity G.;Wenzel, Sally E.
通讯作者：
Wenzel, Sally E.
影响因子：
3
作者：
Cohen, Joel W.;Cohen, Steven B.;Banthin, Jessica S.
通讯作者：
Banthin, Jessica S.
影响因子：
4.3
作者：
Delgado, Ana;Saletti-Cuesta, Lorena;Luna del Castillo, Juan de Dios
通讯作者：
Luna del Castillo, Juan de Dios
影响因子：
5
作者：
Al-Sahab, Ban;Hamadeh, Mazen J.;Tamim, Hala
通讯作者：
Tamim, Hala