Protein palmitoylation in cancer: molecular functions and therapeutic potential.
Protein palmitoylation in cancer: molecular functions and therapeutic potential.
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癌症中的蛋白质棕榈酰化：分子功能和治疗潜力。
DOI：
10.1002/1878-0261.13308
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发表时间：
2023-01
影响因子：
6.6
通讯作者：
Kong, Eryan
中科院分区：
文献类型：
--
作者：
Zhou, Binhui;Hao, Qianyun;Liang, Yinming;Kong, Eryan
蛋白质S-棕榈酰化（以下简称蛋白质棕榈酰化）是由含锌指DHHC-型（ZDHHC）蛋白家族催化的可逆脂质翻译后修饰。逆反应脱棕榈酰化由棕榈酰蛋白硫酯酶（PPT）催化，包括酰基蛋白硫酯酶（APT 1/2）、棕榈酰蛋白硫酯酶（PPT 1/2）或含α/β水解酶结构域的蛋白17 A/B/C（ABHD 17 A/B/C）。多种癌基因和肿瘤抑制因子编码的蛋白质通过棕榈酰化修饰，增强了特定蛋白质亚结构域的疏水性，并可以改变蛋白质稳定性、膜定位、蛋白质-蛋白质相互作用和信号转导。在过去的十年中，蛋白质棕榈酰化在肿瘤发生中的重要性刚刚开始阐明;棕榈酰化似乎影响癌症的关键方面，包括癌细胞增殖和存活，细胞侵袭和转移以及抗肿瘤免疫。在这里，我们回顾了目前的文献中的蛋白质棕榈酰化在各种癌症类型，并讨论了潜在的靶向棕榈酰化酶或棕榈酰化蛋白质的肿瘤治疗。几种癌基因和肿瘤抑制因子被蛋白质棕榈酰化修饰，这是一个由ZDHHC和PPT酶家族动态控制的过程，它们分别添加和去除棕榈酸。棕榈酰化影响蛋白质稳定性、蛋白质-蛋白质相互作用、膜定位和信号转导，从而调节肿瘤存活和肿瘤进展。棕榈酰化酶或棕榈酰化蛋白是肿瘤治疗的潜在靶点。
Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing (ZDHHC) protein family. The reverse reaction, depalmitoylation, is catalyzed by palmitoyl‐protein thioesterases (PPTs), including acyl‐protein thioesterases (APT1/2), palmitoyl protein thioesterases (PPT1/2), or alpha/beta hydrolase domain‐containing protein 17A/B/C (ABHD17A/B/C). Proteins encoded by several oncogenes and tumor suppressors are modified by palmitoylation, which enhances the hydrophobicity of specific protein subdomains, and can confer changes in protein stability, membrane localization, protein–protein interaction, and signal transduction. The importance for protein palmitoylation in tumorigenesis has just started to be elucidated in the past decade; palmitoylation appears to affect key aspects of cancer, including cancer cell proliferation and survival, cell invasion and metastasis, and antitumor immunity. Here we review the current literature on protein palmitoylation in the various cancer types, and discuss the potential of targeting of palmitoylation enzymes or palmitoylated proteins for tumor treatment. Several oncogenes and tumor suppressors are modified by protein palmitoylation, a process that is dynamically controlled by the ZDHHC and PPT enzyme families, which add and remove palmitate, respectively. Palmitoylation affects protein stability, protein–protein interactions, membrane localization, and signaling transduction, thereby regulating tumor survival and tumor progression. Palmitoylation enzymes or palmitoylated proteins are potential targets for tumor treatment.
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影响因子：
13.3
作者：
Brun, Sonia;Bestion, Eloine;Raymond, Eric;Bassissi, Firas;Jilkova, Zuzana Macek;Mezouar, Soraya;Rachid, Madani;Novello, Marie;Tracz, Jennifer;Hamai, Ahmed;Lalmanach, Gilles;Vanderlynden, Lise;Legouffe, Raphael;Stauber, Jonathan;Schubert, Thomas;Plach, Maximilian G.;Courcambeck, Jerome;Drouot, Cyrille;Jacquemot, Guillaume;Serdjebi, Cindy;Roth, Gael;Baudoin, Jean-Pierre;Ansaldi, Christelle;Decaens, Thomas;Halfon, Philippe
通讯作者：
Halfon, Philippe
靶向 MC1R 去棕榈酰化以预防红发黑色素瘤生成
影响因子：
16.6
作者：
Chen, Shuyang;Han, Changpeng;Cui, Rutao
通讯作者：
Cui, Rutao
影响因子：
64.8
作者：
Chen S;Zhu B;Yin C;Liu W;Han C;Chen B;Liu T;Li X;Chen X;Li C;Hu L;Zhou J;Xu ZX;Gao X;Wu X;Goding CR;Cui R
通讯作者：
Cui R
影响因子：
3.3
作者：
Acconcia, F;Ascenzi, P;Marino, M
通讯作者：
Marino, M
影响因子：
4.3
作者：
Bollu, Lakshmi Reddy;Ren, Jiangong;Zhang Weihua
通讯作者：
Zhang Weihua