Mechano-regulation of collagen biosynthesis in periodontal ligament.
Mechano-regulation of collagen biosynthesis in periodontal ligament.
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DOI：
10.1016/j.jpor.2014.08.003
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发表时间：
2014-10
影响因子：
3.6
通讯作者：
Yamauchi, Mitsuo
中科院分区：
文献类型：
--
作者：
Kaku, Masaru;Yamauchi, Mitsuo
牙周韧带在牙周组织的发育和维持中起着至关重要的作用，如牙齿的出牙和咀嚼力的消散。PDL的力学性能主要来源于纤维状I型胶原蛋白，这是最丰富的细胞外成分。I型胶原蛋白的生物合成是一个漫长而复杂的过程，包括许多细胞内和细胞外的翻译后修饰。最后的修饰步骤是形成共价的分子内和分子间交联，为胶原原纤维提供稳定性和连通性。现在很清楚，胶原翻译后修饰是由特定的酶和相关分子以组织特异性的方式调节的；这些变化似乎随着机械力的变化而变化。本文综述了机械载荷对PDL中胶原生物合成和纤维形成的影响，重点介绍了胶原的翻译后修饰，这是修复牙科领域一个重要的分子方面。
Periodontal ligament (PDL) plays critical roles in the development and maintenance of periodontium such as tooth eruption and dissipation of masticatory force. The mechanical properties of PDL are mainly derived from fibrillar type I collagen, the most abundant extracellular component. The biosynthesis of type I collagen is a long, complex process including a number of intra- and extracellular post-translational modifications. The final modification step is the formation of covalent intra- and intermolecular cross-links that provide collagen fibrils with stability and connectivity. It is now clear that collagen post-translational modifications are regulated by groups of specific enzymes and associated molecules in a tissue-specific manner; and these modifications appear to change in response to mechanical force. This review focuses on the effect of mechanical loading on collagen biosynthesis and fibrillogenesis in PDL with emphasis on the post-translational modifications of collagens, which is an important molecular aspect to understand in the field of prosthetic dentistry.
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影响因子：
2.4
作者：
Arnsdorf, Emily J.;Tummala, Padmaja;Castillo, Alesha B.;Zhang, Fan;Jacobs, Christopher R.
通讯作者：
Jacobs, Christopher R.
影响因子：
2.9
作者：
CETTA, G;DELUCA, G;CASTELLANI, AA
通讯作者：
CASTELLANI, AA
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影响因子：
4.8
作者：
Atsawasuwan, Phimon;Mochida, Yoshiyuki;Yamauchi, Mitsuo
通讯作者：
Yamauchi, Mitsuo
影响因子：
4.8
作者：
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通讯作者：
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