Neutrophils and COVID-19: Active Participants and Rational Therapeutic Targets.
Neutrophils and COVID-19: Active Participants and Rational Therapeutic Targets.
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DOI：
10.3389/fimmu.2021.680134
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发表时间：
2021
影响因子：
7.3
通讯作者：
Lord JM
中科院分区：
文献类型：
--
作者：
Hazeldine J;Lord JM
虽然大多数感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）（COVID-19的病原体）的个体会出现轻度至中度症状，但约20%的个体会出现严重的呼吸系统并发症，可能会发展为急性呼吸窘迫综合征、肺衰竭和死亡。迄今为止，基于单细胞和高通量系统的对SARS-CoV-2的外周和肺部免疫应答的分析表明，过度活跃和失调的免疫应答是严重疾病发展的基础，其中中性粒细胞的作用突出。部分特征是中性粒细胞胞外陷阱（NET）的稳健产生，循环中存在未成熟、免疫抑制和活化的中性粒细胞亚群，以及肺中的嗜中性粒细胞浸润，粒细胞特征正在成为严重COVID-19的定义特征。此外，在入院时对循环中性粒细胞的数量、成熟状态和/或功能的评估已显示出作为早期识别具有临床恶化风险的患者的预后工具的前景。在这里，通过总结研究SARS-CoV-2的外周和肺部免疫反应的研究结果，我们提供了一个全面的概述，发生在不同疾病严重程度的COVID-19患者的中性粒细胞池的组成，表型和功能的变化，并讨论了SARS-CoV-2诱导的中性粒细胞功能障碍的潜在介质。由于目前批准用于COVID-19的特定治疗方法很少，我们通过讨论中性粒细胞是否代表治疗严重COVID-19患者的潜在治疗靶点来结束综述。
Whilst the majority of individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19, experience mild to moderate symptoms, approximately 20% develop severe respiratory complications that may progress to acute respiratory distress syndrome, pulmonary failure and death. To date, single cell and high-throughput systems based analyses of the peripheral and pulmonary immune responses to SARS-CoV-2 suggest that a hyperactive and dysregulated immune response underpins the development of severe disease, with a prominent role assigned to neutrophils. Characterised in part by robust generation of neutrophil extracellular traps (NETs), the presence of immature, immunosuppressive and activated neutrophil subsets in the circulation, and neutrophilic infiltrates in the lung, a granulocytic signature is emerging as a defining feature of severe COVID-19. Furthermore, an assessment of the number, maturity status and/or function of circulating neutrophils at the time of hospital admission has shown promise as a prognostic tool for the early identification of patients at risk of clinical deterioration. Here, by summarising the results of studies that have examined the peripheral and pulmonary immune response to SARS-CoV-2, we provide a comprehensive overview of the changes that occur in the composition, phenotype and function of the neutrophil pool in COVID-19 patients of differing disease severities and discuss potential mediators of SARS-CoV-2-induced neutrophil dysfunction. With few specific treatments currently approved for COVID-19, we conclude the review by discussing whether neutrophils represent a potential therapeutic target for the treatment of patients with severe COVID-19.
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DOI：
10.1074/jbc.m110.103275
发表时间：
2010-07-23
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Belouzard S;Madu I;Whittaker GR
通讯作者：
Whittaker GR
影响因子：
4.6
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Morrot A
影响因子：
2.6
作者：
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通讯作者：
Erdem, Deniz
影响因子：
12.3
作者：
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通讯作者：
German COVID-19 Omics Initiative (DeCOI)
DOI：
10.1016/j.xcrm.2021.100229
发表时间：
2021-04-20
期刊：
Cell reports. Medicine
影响因子：
--
作者：
Buehler PK;Zinkernagel AS;Hofmaenner DA;Wendel Garcia PD;Acevedo CT;Gómez-Mejia A;Mairpady Shambat S;Andreoni F;Maibach MA;Bartussek J;Hilty MP;Frey PM;Schuepbach RA;Brugger SD
通讯作者：
Brugger SD