Association of perceived stress and coping strategies with the renal function in middle-aged and older Japanese men and women.
Association of perceived stress and coping strategies with the renal function in middle-aged and older Japanese men and women.
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DOI：
10.1038/s41598-021-04324-2
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发表时间：
2022-01-07
影响因子：
4.6
通讯作者：
Wakai K
中科院分区：
文献类型：
--
作者：
Koga K;Hara M;Shimanoe C;Nishida Y;Furukawa T;Iwasaka C;Tanaka K;Otonari J;Ikezaki H;Kubo Y;Kato Y;Tamura T;Hishida A;Matsuo K;Ito H;Nakamura Y;Kusakabe M;Nishimoto D;Shibuya K;Suzuki S;Watanabe M;Ozaki E;Matsui D;Kuriki K;Takashima N;Kadota A;Arisawa K;Katsuura-Kamano S;Takeuchi K;Wakai K
阐明慢性肾脏病的危险因素对于预防终末期肾脏病和降低死亡率非常重要。然而，很少有人知道的作用，心理社会压力和压力应对行为的肾功能恶化，估计肾小球滤过率（eGFR）的测量。这项针对日本中年和老年男性（n = 31，703）和女性（n = 38，939）的横断面研究调查了感知压力和应对策略（情感表达，情感支持寻求，积极重新评价，解决问题和脱离）是否与eGFR相关，相互作用。在调整了年龄、地区、生活方式因素和社会心理变量的多元线性回归分析中，我们发现男性的压力感知和eGFR之间存在显著的负相关性（P趋势= 0.02），但女性则不然。在调整高血压和糖尿病史后，这种男性特异性的负相关性略有减弱，并且在较低水平的情绪表达中更为明显（P相互作用= 0.003）。出乎意料的是，男性的问题解决（P趋势< 0.001）和女性的积极重新评价（P趋势= 0.002）也显示出与eGFR呈负相关。感知压力可能会影响eGFR，部分是通过发展高血压和糖尿病。关于应对策略的意外发现需要澄清的基本机制，包括激素和免疫方面。
Elucidating the risk factors for chronic kidney disease is important for preventing end-stage renal disease and reducing mortality. However, little is known about the roles of psychosocial stress and stress coping behaviors in deterioration of the renal function, as measured by the estimated glomerular filtration rate (eGFR). This cross-sectional study of middle-aged and older Japanese men (n = 31,703) and women (n = 38,939) investigated whether perceived stress and coping strategies (emotional expression, emotional support seeking, positive reappraisal, problem solving, and disengagement) were related to the eGFR, with mutual interactions. In multiple linear regression analyses adjusted for age, area, lifestyle factors, and psychosocial variables, we found a significant inverse association between perceived stress and the eGFR in men (Ptrend = 0.02), but not women. This male-specific inverse association was slightly attenuated after adjustment for the history of hypertension and diabetes and was more evident in lower levels of emotional expression (Pinteraction = 0.003). Unexpectedly, problem solving in men (Ptrend < 0.001) and positive reappraisal in women (Ptrend = 0.002) also showed an inverse association with the eGFR. Perceived stress may affect the eGFR, partly through the development of hypertension and diabetes. The unexpected findings regarding coping strategies require the clarification of the underlying mechanisms, including the hormonal and immunological aspects.
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影响因子：
3.9
作者：
Cain, Loretta R.;Glover, LaShaunta;Sims, Mario
通讯作者：
Sims, Mario
影响因子：
4.7
作者：
Hara M;Higaki Y;Taguchi N;Shinchi K;Morita E;Naito M;Hamajima N;Takashima N;Suzuki S;Nakamura A;Ohnaka K;Uemura H;Nishida H;Hosono S;Mikami H;Kubo M;Tanaka H;Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group
通讯作者：
Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group
影响因子：
5.5
作者：
Levin, Adeera;Stevens, Paul E.
通讯作者：
Stevens, Paul E.
DOI：
10.1023/b:jocs.0000016265.62022.82
发表时间：
2004-03-01
影响因子：
2.2
作者：
Dreer, LE;Elliott, TR;Tucker, E
通讯作者：
Tucker, E
影响因子：
13.2
作者：
Matsuo, Seiichi;Imai, Enyu;Hishida, Akira
通讯作者：
Hishida, Akira