Input-Specific Long-Term Depression in the Lateral Amygdala Evoked by Theta Frequency Stimulation
Input-Specific Long-Term Depression in the Lateral Amygdala Evoked by Theta Frequency Stimulation
复制标题
Theta 频率刺激引起的外侧杏仁核输入特异性长期抑制
作者：
T. Heinbockel;H. Pape
尽管条件恐惧已被证明涉及杏仁核突触可塑性的机制，但与传入输入系统的关联尚不清楚。在这里，我们报道了在体外大鼠外侧杏仁核刺激假定的丘脑输入纤维而不是皮质输入纤维后的同突触长期抑制（LTD）兴奋反应。LTD是由θ频率刺激诱导的，涉及突触后钙依赖机制和II组代谢性谷氨酸受体。这些突触强度的输入特异性变化代表了潜在的细胞来源，它调节了丘脑和皮层向杏仁核输入信号之间的平衡。在恐惧反应过程中，丘脑传入的相对不区分的刺激信息对大脑皮层介导的区分感觉信息的影响可能会减少。
Although conditioned fear has been shown to involve mechanisms of synaptic plasticity in the amygdala, the association with afferent input systems is not yet clear. Here we report on homosynaptic long-term depression (LTD) of excitatory responses after stimulation of putative thalamic input fibers, but not of cortical inputs, to the rat lateral amygdala in vitro. LTD is induced by theta frequency stimulation and involves postsynaptic calcium-dependent mechanisms and group II metabotropic glutamate receptors. These input-specific changes in synaptic strength represent potential cellular sources, which regulate the balance between sensory thalamic and cortical input signals to the amygdala. This regulation would function to reduce the influence of relatively undiscriminated stimulus information carried by thalamic afferents in favor of discriminated sensory information mediated by the cortex during fear responses.
影响因子：
2.5
作者：
D. Rainnie;E. Asprodini;P. Shinnick‐Gallagher
通讯作者：
D. Rainnie;E. Asprodini;P. Shinnick‐Gallagher
影响因子：
2.5
作者：
D. Rainnie;E. Asprodini;P. Shinnick‐Gallagher
通讯作者：
D. Rainnie;E. Asprodini;P. Shinnick‐Gallagher
影响因子：
2
作者：
Li, XF;Stutzmann, GE;LeDoux, JE
通讯作者：
LeDoux, JE