Dorsal anterior cingulate glutamate is associated with engagement of the default mode network during exposure to smoking cues.
Dorsal anterior cingulate glutamate is associated with engagement of the default mode network during exposure to smoking cues.
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DOI：
10.1016/j.drugalcdep.2016.07.021
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发表时间：
2016-10-01
影响因子：
4.2
通讯作者：
Lukas, Scott E.
中科院分区：
文献类型：
--
作者：
Janes, Amy C.;Betts, Jennifer;Jensen, J. Eric;Lukas, Scott E.
当暴露于吸烟线索时，尼古丁依赖者激活了与默认模式网络（DMN）重叠的大脑区域，这是一个涉及内部聚焦认知的区域网络。突出网络（SN），包括背前扣带皮层（dACC），被认为与DMN相互作用，并有助于将注意力导向显著的内部或外部刺激。一种可能性是，像dACC这样的SN区域的神经化学变化影响了DMN对个人相关刺激（如吸烟线索）的反应性。这与新出现的证据一致，表明中线皮质谷氨酸（Glu）与与DMN重叠的大脑区域的活动之间存在关联。在18名尼古丁依赖的个体中，我们使用功能性磁共振成像和磁共振波谱测量的dACC Glu来评估DMN激活与吸烟相对于中性线索的关系。这种关联也在14名尼古丁依赖参与者的重复样本中进行了测试。在吸烟提示暴露过程中，DMN的抑制程度明显降低，而且DMN对吸烟的反应性与dACC Glu之间存在正相关（r = 0.56, p < 0.02）。这一发现在独立复制队列中得到证实（r = 0.64, p < 0.02）。目前的研究结果证实，与中性线索相比，吸烟者看到吸烟时DMN受到的抑制较少，这表明吸烟线索参与了自我相关处理。此外，这些结果表明，当尼古丁依赖个体暴露于自我相关的吸烟提示时，dACC Glu与DMN参与增强有关。
When exposed to smoking cues, nicotine dependent individuals activate brain regions overlapping with the default mode network (DMN), a network of regions involved in internally-focused cognition. The salience network (SN), which includes the dorsal anterior cingulate cortex (dACC), is thought to interact with the DMN and aids in directing attention toward salient internal or external stimuli. One possibility is that neurochemical variation in SN regions such as the dACC impact DMN reactivity to personally relevant stimuli such as smoking cues. This is consistent with emerging evidence suggesting an association between midline cortical glutamate (Glu) and activity in brain regions overlapping with the DMN. In 18 nicotine-dependent individuals, we assessed the relationship between DMN activation to smoking relative to neutral cues using functional magnetic resonance imaging and dACC Glu as measured by magnetic resonance spectroscopy. This association also was tested in a replication sample of 14 nicotine-dependent participants. Not only was the DMN significantly less suppressed during smoking cue exposure, but also there was a positive association between DMN reactivity to smoking relative to neutral cues and dACC Glu (r = 0.56, p < 0.02). This finding was confirmed in the independent replication cohort (r = 0.64, p < 0.02). The current findings confirm that the DMN is less suppressed when smokers view smoking relative to neutral cues, suggesting that smoking cues engage self-relevant processing. Furthermore, these results indicate that dACC Glu is associated with enhanced DMN engagement when nicotine-dependent individuals are exposed to self-relevant smoking cues.
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影响因子：
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作者：
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