Nanotechnology for cardiovascular diseases.
Nanotechnology for cardiovascular diseases.
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纳米技术治疗心血管疾病
DOI：
10.1016/j.xinn.2022.100214
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发表时间：
2022-03-29
期刊：
影响因子：
--
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Hu Q;Fang Z;Ge J;Li H
心血管疾病已成为当今世界的主要杀手，其中冠状动脉疾病（CADs）对发病率和死亡率的贡献最大。尽管最先进的技术增加了我们对心血管系统的了解，但目前对心血管疾病的诊断和治疗方式仍然存在局限性。纳米技术作为一种新兴的跨学科方法，在临床应用中显示出巨大的潜力。本文首先综述了近年来纳米技术在cad诊断中的研究进展。在纳米材料的帮助下，用于生物标志物检测和分子成像策略（如磁共振成像、光学成像、核闪烁成像和多模态成像策略）的生物传感器的灵敏度和特异性都得到了极大的提高。其次，各种纳米材料，如脂质体、聚合物（PLGA）、无机纳米颗粒（AuNPs、MnO2等）、天然纳米颗粒（HDL、HA）和仿生纳米颗粒（细胞膜涂层），将根据其最佳的物理化学性质和表面修饰潜力，作为靶向病理部位的药物（化学品、蛋白质、肽和核酸）载体进行工程研究。最后，其中一些纳米材料本身被认为是治疗动脉粥样硬化的药物，因为它们在复杂斑块微环境中具有固有的抗氧化/抗炎和光电/光热特性。综上所述，在可预见的未来，基于纳米技术的新型临床转化研究将继续扩大纳米技术在cad诊断和治疗中的应用范围。纳米技术为心血管疾病的诊断和治疗提供了新的可行方法，这是世界范围内发病率和死亡率的主要原因。纳米技术辅助的生物传感和分子成像可以提高心血管疾病诊断的敏感性和特异性。纳米材料基于其物理化学性质和表面修饰，可以靶向给药或直接对心血管系统发挥治疗作用
Cardiovascular diseases have become the major killers in today's world, among which coronary artery diseases (CADs) make the greatest contributions to morbidity and mortality. Although state-of-the-art technologies have increased our knowledge of the cardiovascular system, the current diagnosis and treatment modalities for CADs still have limitations. As an emerging cross-disciplinary approach, nanotechnology has shown great potential for clinical use. In this review, recent advances in nanotechnology in the diagnosis of CADs will first be elucidated. Both the sensitivity and specificity of biosensors for biomarker detection and molecular imaging strategies, such as magnetic resonance imaging, optical imaging, nuclear scintigraphy, and multimodal imaging strategies, have been greatly increased with the assistance of nanomaterials. Second, various nanomaterials, such as liposomes, polymers (PLGA), inorganic nanoparticles (AuNPs, MnO2, etc.), natural nanoparticles (HDL, HA), and biomimetic nanoparticles (cell-membrane coating) will be discussed as engineered as drug (chemicals, proteins, peptides, and nucleic acids) carriers targeting pathological sites based on their optimal physicochemical properties and surface modification potential. Finally, some of these nanomaterials themselves are regarded as pharmaceuticals for the treatment of atherosclerosis because of their intrinsic antioxidative/anti-inflammatory and photoelectric/photothermal characteristics in a complex plaque microenvironment. In summary, novel nanotechnology-based research in the process of clinical transformation could continue to expand the horizon of nanoscale technologies in the diagnosis and therapy of CADs in the foreseeable future. Nanotechnology represents new viable approaches for diagnosis and treatment of cardiovascular diseases, the leading cause of morbidity and mortality worldwide Nanotechnology-assisted biosensing and molecular imaging can improve the sensitivity and specificity in the diagnosis of cardiovascular diseases Nanomaterials enable targeted drug delivery or directly exert therapeutic action for cardiovascular system, based on their physicochemical properties and surface modification
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影响因子：
14
作者：
Daghem, Marwa;Bing, Rong;Fayad, Zahi A.;Dweck, Marc R.
通讯作者：
Dweck, Marc R.
影响因子：
5.9
作者：
Benstoem C;Goetzenich A;Kraemer S;Borosch S;Manzanares W;Hardy G;Stoppe C
通讯作者：
Stoppe C
影响因子：
17.1
作者：
Beldman TJ;Senders ML;Alaarg A;Pérez-Medina C;Tang J;Zhao Y;Fay F;Deichmöller J;Born B;Desclos E;van der Wel NN;Hoebe RA;Kohen F;Kartvelishvily E;Neeman M;Reiner T;Calcagno C;Fayad ZA;de Winther MPJ;Lutgens E;Mulder WJM;Kluza E
通讯作者：
Kluza E
影响因子：
37.8
作者：
Colombo, A;Drzewiecki, J;Russell, ME
通讯作者：
Russell, ME
影响因子：
17.1
作者：
Beldman, Thijs J.;Malinova, Tsveta S.;Kluza, Ewelina
通讯作者：
Kluza, Ewelina