Selenium and its supplementation in cardiovascular disease--what do we know?
Selenium and its supplementation in cardiovascular disease--what do we know?
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DOI：
10.3390/nu7053094
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发表时间：
2015-04-27
期刊：
影响因子：
5.9
通讯作者：
Stoppe C
中科院分区：
文献类型：
--
作者：
Benstoem C;Goetzenich A;Kraemer S;Borosch S;Manzanares W;Hardy G;Stoppe C
微量元素硒对于身体的许多调节和代谢功能具有高度重要性。平衡的硒水平是必不可少的，而失调可能会造成伤害。越来越多的研究揭示了硒在人体中广泛的功能，阐明了硒和硒蛋白之间复杂的生理和病理生理相互作用。对于大多数硒依赖性酶，已经确定了几种生物学功能，如炎症反应的调节，抗氧化特性和免疫细胞的增殖/分化。虽然硒在心血管疾病的发展和进展中的潜在作用已经研究了几十年，但硒补充的观察性和干预性研究仍然没有定论，并在本文中进行了审查。本文综述了硒和硒蛋白在人体中的作用及其在心血管系统中的功能作用。硒摄入量/状态和各种健康结果之间的关系，特别是心肌病，心肌缺血/梗死和再灌注损伤。我们深入描述了硒作为冠心病的生物标志物，并强调了补充硒对心脏手术患者的重要性。
The trace element selenium is of high importance for many of the body’s regulatory and metabolic functions. Balanced selenium levels are essential, whereas dysregulation can cause harm. A rapidly increasing number of studies characterizes the wide range of selenium dependent functions in the human body and elucidates the complex and multiple physiological and pathophysiological interactions of selenium and selenoproteins. For the majority of selenium dependent enzymes, several biological functions have already been identified, like regulation of the inflammatory response, antioxidant properties and the proliferation/differentiation of immune cells. Although the potential role of selenium in the development and progression of cardiovascular disease has been investigated for decades, both observational and interventional studies of selenium supplementation remain inconclusive and are considered in this review. This review covers current knowledge of the role of selenium and selenoproteins in the human body and its functional role in the cardiovascular system. The relationships between selenium intake/status and various health outcomes, in particular cardiomyopathy, myocardial ischemia/infarction and reperfusion injury are reviewed. We describe, in depth, selenium as a biomarker in coronary heart disease and highlight the significance of selenium supplementation for patients undergoing cardiac surgery.
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影响因子：
2.5
作者：
Alvarenga Americano do Brasil PE;Pereira de Souza A;Hasslocher-Moreno AM;Xavier SS;Lambert Passos SR;de Fátima Ramos Moreira M;Santini de Oliveira M;Sperandio da Silva GM;Magalhães Saraiva R;Santos de Aguiar Cardoso C;de Sousa AS;Mediano MF;Bonecini de Almeida Mda G;da Cruz Moreira O;Britto C;de Araújo-Jorge TC
通讯作者：
de Araújo-Jorge TC
影响因子：
5.5
作者：
Ahrens, Ingo;Ellwanger, Christoph;Peter, Karlheinz
通讯作者：
Peter, Karlheinz
影响因子：
--
作者：
Bleys, Joachim;Navas-Acien, Ana;Guallar, Eliseo
通讯作者：
Guallar, Eliseo
影响因子：
7.1
作者：
Flores-Mateo, Gemma;Navas-Acien, Ana;Guallar, Eliseo
通讯作者：
Guallar, Eliseo
影响因子：
3.8
作者：
Cox, Amanda. J.;Lehtinen, Allison B.;Xu, Jianzhao;Langefeld, Carl D.;Freedman, Barry I.;Carr, J. Jeffrey;Bowden, Donald W.
通讯作者：
Bowden, Donald W.