Effect of Angelica polysaccharide on mouse myeloid-derived suppressor cells.
Effect of Angelica polysaccharide on mouse myeloid-derived suppressor cells.
复制标题
当归多糖对小鼠髓系抑制细胞的影响
DOI：
10.3389/fimmu.2022.989230
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发表时间：
2022
影响因子：
7.3
通讯作者：
Peng, Meiyu
中科院分区：
文献类型：
--
作者：
Shen, Jie;Zhang, Mengyu;Zhang, Ke;Qin, Yahan;Liu, Meifang;Liang, Shujuan;Chen, Daquan;Peng, Meiyu
关键词：
当归多糖（Angelica polysaccharide，APS）是从当归中提取的一种多糖，是当归的主要活性成分之一。许多研究表明，APS能促进多种免疫细胞的活化和功能，是公认的免疫增强剂，但其对骨髓源性抑制细胞（MDSC）的调节作用尚不清楚。本研究通过体内外实验研究黄芪多糖对MDSC增殖、分化和功能的影响。体外实验结果表明，APS通过STAT 1和STAT 3信号通路促进MDSC的增殖、分化和免疫抑制功能，并与甘露糖受体（MR，又称CD 206）的表达水平呈正相关，且对APS呈浓度依赖性。在体内，APS可不同程度地上调小鼠外周血和脾脏中的T细胞、γδT细胞、CD 8 +T细胞、自然杀伤细胞、单核/巨噬细胞和粒细胞，并伴有同等程度的MDSC比例增加。提示临床医生在应用APS治疗时应注意其可能引起的增加MDSC数量和功能的副作用，以提高疗效。
Angelica polysaccharide (APS) is a polysaccharide extracted from Angelica sinensis and it is one of the main active components of Angelica sinensis. Many studies have demonstrated that APS can promote the activation and function of a variety of immune cells and is recognized as an immune enhancer, but the regulatory effect of APS on myeloid-derived suppressor cells (MDSC) is still unclear. In this study, we investigated the effects of APS on MDSC proliferation, differentiation and function through in vivo and in vitro experiments. In vitro, our results showed that APS promoted the proliferation, differentiation and immunosuppressive function of MDSC through STAT1 and STAT3 signaling pathways, and positively correlated with the expression level of Mannose receptor (MR, also known as CD206) and in a concentration-dependent manner on APS. In vivo, APS up-regulated T cells, γδT cells, CD8+T cells, natural killer cells, monocytes/macrophages, and granulocytes in the peripheral blood and spleen of mice to varying degrees and was accompanied by the same degree of increase in the proportion of MDSC. That reminds to the clinician that when applying APS as treatment they should pay attention to its possible side effects of increasing the quantity and function of MDSC, in order to increase its efficacy.
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影响因子：
11.2
作者：
Xin H;Zhang C;Herrmann A;Du Y;Figlin R;Yu H
通讯作者：
Yu H
DOI：
10.1016/j.jbc.2021.100368
发表时间：
2021-01
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Feinberg H;Jégouzo SAF;Lasanajak Y;Smith DF;Drickamer K;Weis WI;Taylor ME
通讯作者：
Taylor ME
影响因子：
5.6
作者：
Kim, Jee Youn;Yoon, Yeo Dae;Han, Sang-Bae
通讯作者：
Han, Sang-Bae
影响因子：
7.3
作者：
van der Zande HJP;Nitsche D;Schlautmann L;Guigas B;Burgdorf S
通讯作者：
Burgdorf S
Embelin 通过直接诱导癌细胞凋亡和间接限制 IL-6 相关炎症和免疫抑制细胞来抑制胰腺癌进展。
影响因子：
9.7
作者：
Peng, Meiyu;Huang, Bingqing;Zhang, Rongxin
通讯作者：
Zhang, Rongxin