Small-cell lung cancer-associated autoantibodies: potential applications to cancer diagnosis, early detection, and therapy.
Small-cell lung cancer-associated autoantibodies: potential applications to cancer diagnosis, early detection, and therapy.
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DOI：
10.1186/1476-4598-10-33
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发表时间：
2011-03-30
期刊：
影响因子：
37.3
通讯作者：
Laird-Offringa IA
中科院分区：
文献类型：
--
作者：
Kazarian M;Laird-Offringa IA
小细胞肺癌（SCLC）是最具侵袭性的肺癌亚型，缺乏有效的早期检测方法和治疗。一些罕见的副肿瘤性神经系统自身免疫性疾病与小细胞肺癌密切相关。大多数患有这种副肿瘤综合征的患者具有针对在SCLC肿瘤中异常表达的神经元蛋白的高滴度抗体。这些自身抗体可能与神经系统发生交叉反应，可能导致自身免疫性疾病的发展。重要的是，类似的抗体存在于许多没有自身免疫性疾病的SCLC患者中，尽管滴度较低。自身抗体发展相对于癌症的时间和免疫触发的性质仍有待阐明。在这里，我们回顾了目前已知的SCLC相关的自身抗体，并描述了最近开发的小鼠模型系统的SCLC，似乎借给自己以及SCLC相关的免疫反应的研究。我们还讨论了这些自身抗体的潜在临床应用，如小细胞肺癌的诊断，早期检测和治疗。
Small-cell lung cancer (SCLC) is the most aggressive lung cancer subtype and lacks effective early detection methods and therapies. A number of rare paraneoplastic neurologic autoimmune diseases are strongly associated with SCLC. Most patients with such paraneoplastic syndromes harbor high titers of antibodies against neuronal proteins that are abnormally expressed in SCLC tumors. These autoantibodies may cross-react with the nervous system, possibly contributing to autoimmune disease development. Importantly, similar antibodies are present in many SCLC patients without autoimmune disease, albeit at lower titers. The timing of autoantibody development relative to cancer and the nature of the immune trigger remain to be elucidated. Here we review what is currently known about SCLC-associated autoantibodies, and describe a recently developed mouse model system of SCLC that appears to lend itself well to the study of the SCLC-associated immune response. We also discuss potential clinical applications for these autoantibodies, such as SCLC diagnosis, early detection, and therapy.
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影响因子：
5.3
作者：
Bazhin, AV;Savchenko, MS;Philippov, PP
通讯作者：
Philippov, PP
影响因子：
3.9
作者：
Aguirre-Cruz, L;Charuel, JL;Musset, L
通讯作者：
Musset, L
DOI：
10.1073/pnas.96.17.9885
发表时间：
1999-08-17
影响因子：
11.1
作者：
Akamatsu, W;Okano, HJ;Okano, H
通讯作者：
Okano, H
影响因子：
9.9
作者：
CHALK, CH;MURRAY, NMF;SPIRO, SG
通讯作者：
SPIRO, SG
影响因子：
37.3
作者：
Anglim, Paul P.;Alonzo, Todd A.;Laird-Offringa, Ite A.
通讯作者：
Laird-Offringa, Ite A.