Prognostic and predictive role of JWA and XRCC1 expression in gastric cancer
Prognostic and predictive role of JWA and XRCC1 expression in gastric cancer
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JWA和XRCC1表达在胃癌中的预后和预测作用
DOI：
10.14869/toxpt.39.2.0.ap-201.0
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发表时间：
2012
影响因子：
11.5
通讯作者：
王守宇
中科院分区：
文献类型：
--
作者：
王守宇
目的：探讨DNA修复基因JWA和XRCC 1在胃癌组织中的表达及其意义。实验设计：在训练队列中通过免疫组织化学评估JWA和XRCC 1的表达，然后进入第二个测试队列，最后进入验证队列。分别评价JWA和XRCC 1表达状态在单独手术或联合辅助化疗治疗的病例中的预后和预测作用。结果：胃癌组织中JWA和XRCC 1蛋白表达水平较癌旁组织明显下调。肿瘤JWA或XRCC 1低表达与较短的总生存期（OS）以及未经辅助治疗的患者的临床病理特征显著相关。多变量回归分析显示，JWA和XRCC 1的低表达，单独和一起，是独立的OS阴性标志物。与单纯手术相比，辅助氟尿嘧啶-亚叶酸-奥沙利铂（FLO）显著改善OS（对数秩检验，P = 0.01）。然而，这种作用仅在JWA或XRCC 1低表达组中明显。（HR = 0.44; 95%CI = 0.26-0.73; P = 0.002; HR = 0.44; 95%CI = 0.26-0.75; P = 0.002）;辅助氟尿嘧啶-亚叶酸-铂（FLP）并没有改善OS，除了在低JWA和XRCC 1表达的患者中（JWA的P = 0.010，XRCC 1的P = 0.024）。结论：肿瘤中JWA和XRCC 1蛋白的表达是可切除的人胃癌辅助铂类化疗（FLO或FLP）获益的新的候选预后标志物和预测因素。
Purpose: To investigate the expression pattern and significance of DNA repair genes JWA and XRCC1 in gastric cancer. Experimental Design: Expressions of JWA and XRCC1 were assessed by immunohistochemistry in a training cohort and they went into a second testing cohort and finally to a validating cohort. Prognostic and predictive role of JWA and XRCC1 expression status in cases treated with surgery alone or combined with adjuvant chemotherapy was evaluated, respectively. Results: JWA and XRCC1 protein levels were significantly downregulated in gastric cancer lesions compared with adjacent non-cancerous tissues. Low tumoral JWA or XRCC1 expression significantly correlated with shorter overall survival (OS), as well as with clinicopathologic characteristics in patients without adjuvant treatment. Multivariate regression analysis showed that low JWA and XRCC1 expression, separately and together, were independent negative markers of OS. Adjuvant fluorouracil-leucovorin-oxaliplatin (FLO) significantly improved OS compared with surgery alone (log-rank test, P = 0.01). However, this effect was evident only in the JWA or XRCC1 low expression group (HR = 0.44; 95% CI = 0.26-0.73; P = 0.002, and HR = 0.44; 95% CI = 0.26-0.75; P = 0.002, respectively); Adjuvant fluorouracil-leucovorin-platinol (FLP) did not improve OS, except in the patients with low JWA and XRCC1expression (P = 0.010 for JWA and P = 0.024 for XRCC1, respectively). Conclusions: JWA and XRCC1 protein expression in tumor are novel candidate prognostic markers and predictive factors for benefit from adjuvant platinum-based chemotherapy (FLO or FLP) in resectable human gastric carcinoma.
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影响因子：
11.4
作者：
Kubota, Y;Nash, RA;Lindahl, T
通讯作者：
Lindahl, T
DOI：
--
发表时间：
1998
期刊：
Current biology : CB
影响因子：
--
作者：
R. Taylor;B. Wickstead;S. Cronin;K. Caldecott
通讯作者：
R. Taylor;B. Wickstead;S. Cronin;K. Caldecott
影响因子：
45.3
作者：
Camp, Robert L.;Neumeister, Veronique;Rimm, David L.
通讯作者：
Rimm, David L.
影响因子：
8
作者：
Crnogorac-Jurcevic, T;Efthimiou, E;Lemoine, NR
通讯作者：
Lemoine, NR
影响因子：
4.8
作者：
Chen, Hairong;Bai, Jin;Zhou, Jianwei
通讯作者：
Zhou, Jianwei