Dynamic PET/CT Imaging of (68)Ga-FAPI-04 in Chinese Subjects.
Dynamic PET/CT Imaging of (68)Ga-FAPI-04 in Chinese Subjects.
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68Ga-FAPI-04在中国受试者中的动态PET/CT成像
DOI：
10.3389/fonc.2021.651005
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发表时间：
2021
影响因子：
4.7
通讯作者：
Yang Z
中科院分区：
文献类型：
--
作者：
Wang S;Zhou X;Xu X;Ding J;Liu T;Jiang J;Li N;Zhu H;Yang Z
本研究旨在进一步探索健康中国受试者和肺癌患者的68Ga-FAPI-04 PET/CT动态成像。此外，测量正常器官中68Ga-FAPI-04摄取的变异性，以提供分析其生物分布、解释辅助图像、确定图像定量的可靠性和监测治疗的基础。6名患者（3名无肿瘤受试者和3名肺癌患者）在1周内分别接受了68Ga-FAPI-04和2-[18F] FDG PET/CT成像。报告了生物分布和内照射剂量测定，并与以前从白人患者中获得的数据进行了比较。此外，将平均SUV（标准化摄取值）标准化为体重或瘦体重（SUL），计算变异系数（CV）并比较每个感兴趣体积。计算出的平均全身有效剂量为1.27E-02 mSv/MBq，这与先前报道的68Ga-FAPI-04探针的结果相当。此外，在大多数器官中，SUV平均值略高于SU平均值;然而，在随后的时间点，大多数器官的SU平均值的CV高于SUV平均值。在肝脏中，SUV平均值的CV（12.7%）低于SU平均值，与相应2-[18 F] FDG PET/CT值的CV（11.8%）相似。此外，68Ga-FAPI-04 PET/CT在本研究中对肺癌患者的诊断显示出良好的疗效。之前从高加索人群获得的辐射剂量测定的比较表明，在68Ga-FAPI-04注射后，这两个人群之间没有临床显著差异。SUVmean在大多数器官中的变异性略低于SULmean，表明SUVmean可能是量化68Ga-FAPI-04获得的图像的首选参数。此外，68Ga-FAPI-04 PET/CT成像有望成为诊断肺癌的有前途的工具。
This study aims to further explore dynamic 68Ga-FAPI-04 PET/CT imaging of healthy Chinese subjects and lung cancer patients. Moreover, the variability of 68Ga-FAPI-04 uptake in normal organs was measured to provide a basis for analyzing its biological distribution, interpreting auxiliary images, determining the reliability of image quantification, and monitoring treatment. Six patients (3 subjects without tumors and 3 lung cancer patients) separately underwent 68Ga-FAPI-04 and 2-[18F]FDG PET/CT imaging within 1 week. The biodistribution and internal radiation dosimetry were reported and compared with data previously obtained from Caucasian patients. Moreover, the mean SUV (standardized uptake value) was normalized to body mass or to lean body mass (SUL), and the coefficients of variation (CVs) were calculated and compared for each volume of interest. The average whole-body effective dose was calculated to be 1.27E-02 mSv/MBq, which was comparable with previously reported results of 68Ga-FAPI-04 probes. Furthermore, the SUVmean was slightly higher than the SULmean in most organs; however, the CV of the SULmean for most organs was higher than that of the SUVmean at later time points. In the liver, the CV of the SUVmean was lower (12.7%) than that of the SULmean and was similar to the CV for corresponding 2-[18F]FDG PET/CT value (11.8%). In addition, 68Ga-FAPI-04 PET/CT showed good efficacy for diagnosing lung cancer patients in this study. A comparison of the radiation dosimetry obtained before from a Caucasian population demonstrated no clinically significant differences between these two populations after 68Ga-FAPI-04 injection. The variability in most organs was slightly lower for SUVmean than for SULmean, suggesting that SUVmean may be the preferable parameter for quantifying images obtained with 68Ga-FAPI-04. In addition, 68Ga-FAPI-04 PET/CT imaging is expected to be a promising tool for diagnosing lung cancer.
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通讯作者：
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