Regulation of B1 cell migration by signals through Toll-like receptors.
Regulation of B1 cell migration by signals through Toll-like receptors.
复制标题
通过信号通过Toll样受体来调节B1细胞迁移。
DOI：
10.1084/jem.20061041
复制
发表时间：
2006-10-30
期刊：
影响因子：
--
通讯作者：
Fagarasan S
中科院分区：
文献类型：
--
作者：
Ha SA;Tsuji M;Suzuki K;Meek B;Yasuda N;Kaisho T;Fagarasan S
已知腹膜B1细胞在其居住部位外产生大量抗体。这些抗体在建立适应性免疫应答之前，在针对细菌和病毒的早期防御中发挥重要作用。虽然许多刺激，包括抗原，脂多糖，或细胞因子，已被证明激活B1细胞，并诱导其分化为浆细胞，所需的分子信号，他们从腹膜腔的出口不了解。我们在这里证明，通过Toll样受体（TLR）的直接信号诱导特定的，快速的，和短暂的下调整合素和CD9的B1细胞，这是必要的脱离当地的矩阵和高速运动的细胞响应趋化因子。因此，我们揭示了一个意想不到的作用，TLR在管理整合素，四跨膜蛋白和趋化因子受体之间的相互作用所需的B1细胞的出口，因此，在促进适当的过渡从先天性适应性免疫反应。
Peritoneal B1 cells are known to generate large amounts of antibodies outside their residential site. These antibodies play an important role in the early defense against bacteria and viruses, before the establishment of adaptive immune responses. Although many stimuli, including antigen, lipopolysaccharide, or cytokines, have been shown to activate B1 cells and induce their differentiation into plasma cells, the molecular signals required for their egress from the peritoneal cavity are not understood. We demonstrate here that direct signals through Toll-like receptors (TLRs) induce specific, rapid, and transient down-regulation of integrins and CD9 on B1 cells, which is required for detachment from local matrix and a high velocity movement of cells in response to chemokines. Thus, we revealed an unexpected role for TLRs in governing the interplay between integrins, tetraspanins, and chemokine receptors required for B1 cell egress and, as such, in facilitating appropriate transition from innate to adaptive immune responses.
登录
查看更多内容
影响因子：
15.3
作者：
Bowman, E P;Campbell, J J;Soler, D;Dong, Z;Manlongat, N;Picarella, D;Hardy, R R;Butcher, E C
通讯作者：
Butcher, E C
影响因子：
32.4
作者：
Alugupalli, KR;Leong, JM;Gerstein, RM
通讯作者：
Gerstein, RM
影响因子：
4.4
作者：
Kaisho, T;Hoshino, K;Akira, S
通讯作者：
Akira, S
影响因子：
2.2
作者：
Kanegasaki, S;Nomura, Y;Kikuchi, Y
通讯作者：
Kikuchi, Y
影响因子：
56.9
作者：
Macpherson, AJ;Gatto, D;Zinkernagel, RM
通讯作者：
Zinkernagel, RM