Brain areas coactivating with motor cortex during chronic motor tics and intentional movements.
Brain areas coactivating with motor cortex during chronic motor tics and intentional movements.
复制标题
DOI：
10.1016/j.biopsych.2008.11.012
复制
发表时间：
2009-04-01
影响因子：
10.6
通讯作者：
Leckman, James F.
中科院分区：
文献类型：
--
作者：
Hampson, Michelle;Tokoglu, Fuyuze;King, Robert A.;Constable, R. Todd;Leckman, James F.
慢性抽动障碍的特征是运动性抽动，通常在此之前有先兆性冲动“抽动”。功能性神经影像学研究已经记录了抽搐之前和抽搐期间的大脑活动模式，但这些研究没有检查激活模式是否与正常对照组进行类似行为时的激活模式不同。一种新的方法被用来比较抽搐和有意运动时的大脑模式。首先，确定了每个患者抽搐运动的特定运动皮层部分。然后通过将局部运动区域的时间过程与其他脑区的活动进行时间交叉相关来识别抽搐期间运动皮层的该部分之前、期间和之后激活的脑区。由于运动皮层在抽搐执行过程中是活跃的，这就产生了关于运动之前、期间和之后活跃的大脑区域的信息。与运动皮层的协同激活的时空模式，在抽搐过程中与健康对照组在故意的“抽搐样”运动进行了对比。来自16名患有抽动障碍的成年受试者和16名匹配的对照组的数据显示，两组中整个大脑的运动皮层的交叉相关模式几乎相同。然而，辅助运动区显示出一个更广泛的配置文件的交叉相关运动皮层在抽搐比在有意的运动。这些发现强调了辅助运动区在抽搐产生中的重要性，并可能为患有严重抽搐的个体提供新的干预策略。
Chronic tic disorders are characterized by motor tics that are often preceded by premonitory urges to “tic.” Functional neuroimaging studies have documented brain activity patterns prior to and during tics, but these studies have not examined whether the activation patterns differ from those seen in normal controls performing similar acts. A novel method was used to compare brain patterns during tics and intentional movements. First, the part of motor cortex specific to each patient's tic movement was identified. The brain areas activating prior to, during, and after that part of motor cortex during tics were then identified by temporally cross-correlating the time-course of the localized motor region with activity in other brain areas. Given that motor cortex was active during tic execution, this yielded information regarding the brain areas active prior to, during, and after the movements. The spatiotemporal pattern of co-activation with motor cortex during tics was contrasted with that seen in healthy controls during intentional “tic-like” movements. Data from 16 adult subjects with tic disorders and 16 matched controls, that performed intentional movements similar to the patients' tics, revealed nearly identical patterns of cross-correlation to motor cortex throughout the brain in the two groups. However, the supplementary motor area showed a significantly broader profile of cross-correlation to motor cortex during tics than during intentional movements. These findings highlight the importance of the supplementary motor area in tic generation and may point toward novel intervention strategies for individuals suffering with severe tics.
登录
查看更多内容
影响因子：
11.2
作者：
Garraux, G;Goldfine, A;Hallett, M
通讯作者：
Hallett, M
影响因子：
9.9
作者：
LANG, A
通讯作者：
LANG, A
影响因子：
3.3
作者：
BANDETTINI, PA;JESMANOWICZ, A;HYDE, JS
通讯作者：
HYDE, JS
影响因子：
4.8
作者：
Hampson, M;Peterson, BS;Gore, JC
通讯作者：
Gore, JC
影响因子：
9.9
作者：
Eidelberg, D;Moeller, JR;Feigin, A
通讯作者：
Feigin, A