Measuring Surrogacy in Clinical Research: With an application to studying surrogate markers for HIV Treatment-as-Prevention.
Measuring Surrogacy in Clinical Research: With an application to studying surrogate markers for HIV Treatment-as-Prevention.
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DOI：
10.1007/s12561-019-09244-4
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发表时间：
2020-12
影响因子：
1
通讯作者：
Chen YQ
中科院分区：
文献类型：
--
作者：
Zhuang R;Chen YQ
In clinical research, validated surrogate markers are highly desirable in study design, monitoring, and analysis, as they do not only reduce the required sample size and follow-up duration, but also facilitate scientific discoveries. However, challenges exist to identify a reliable marker. One particular statistical challenge arises on how to measure and rank the surrogacy of potential markers quantitatively. We review the main statistical methods for evaluating surrogate markers. In addition, we suggest a new measure, the so-called “population surrogacy fraction of treatment effect,” or simply the p-measure, in the setting of clinical trials. The p-measure carries an appealing population impact interpretation and supplements the existing statistical measures of surrogacy by providing “absolute” information. We apply the new measure along with other prominent measures to the HIV Prevention Trial Network 052 Study, a landmark trial for HIV/AIDS treatment-as-prevention.
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DOI：
10.1056/nejmoa1600693
发表时间：
2016-09-01
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cohen MS;Chen YQ;McCauley M;Gamble T;Hosseinipour MC;Kumarasamy N;Hakim JG;Kumwenda J;Grinsztejn B;Pilotto JH;Godbole SV;Chariyalertsak S;Santos BR;Mayer KH;Hoffman IF;Eshleman SH;Piwowar-Manning E;Cottle L;Zhang XC;Makhema J;Mills LA;Panchia R;Faesen S;Eron J;Gallant J;Havlir D;Swindells S;Elharrar V;Burns D;Taha TE;Nielsen-Saines K;Celentano DD;Essex M;Hudelson SE;Redd AD;Fleming TR;HPTN 052 Study Team
通讯作者：
HPTN 052 Study Team
影响因子：
1.9
作者：
Alonso, A;Molenberghs, G;Buyse, M
通讯作者：
Buyse, M
DOI：
10.1097/qai.0b013e3181d61c2e
发表时间：
2010-07
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Chen YQ;Young A;Brown ER;Chasela CS;Fiscus SA;Hoffman IF;Valentine M;Emel L;Taha TE;Goldenberg RL;Read JS
通讯作者：
Read JS
影响因子：
2.9
作者：
BOISSEL, JP;COLLET, JP;HAUGH, M
通讯作者：
HAUGH, M
影响因子：
6.4
作者：
DeGruttola, V;Fleming, T;Coombs, R
通讯作者：
Coombs, R