MDMA produces a delayed and sustained increase in the extracellular concentration of glutamate in the rat hippocampus.
MDMA produces a delayed and sustained increase in the extracellular concentration of glutamate in the rat hippocampus.
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DOI：
10.1016/j.neuropharm.2012.07.026
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发表时间：
2012-11
影响因子：
4.7
通讯作者：
Gudelsky GA
中科院分区：
文献类型：
--
作者：
Anneken JH;Gudelsky GA
MDMA（3，4-亚甲二氧基甲基苯丙胺）对大鼠脑中单胺能和胆碱能系统的神经化学作用已有充分的文献记载。然而，关于MDMA对大脑中的多巴胺能系统的影响知之甚少。在本研究中，研究了多次注射MDMA对纹状体、前额叶皮质和背侧海马细胞外谷氨酸浓度的影响。注射2次或4次（但不是1次）MDMA（10 mg/kg，腹腔注射，间隔2小时）导致海马中谷氨酸的细胞外浓度增加2-3倍;纹状体或前额皮质中未见明显增加。将MDMA（100 µM）反向透析到海马中也引起细胞外谷氨酸盐的增加。用5-HT再摄取抑制剂氟西汀治疗可以防止MDMA全身给药后海马细胞外谷氨酸的增加，用5-HT 2A/C受体拮抗剂酮色林治疗也是如此。此外，反向透析的钠通道阻滞剂河豚毒素并没有阻止海马细胞外谷氨酸的增加。这些数据支持这样的观点，即MDMA释放的5-HT刺激非神经元细胞上的5-HT 2A/2C受体，促进海马中的谷氨酸流出。
The neurochemical effects of MDMA (3,4-methylenedioxymethamphetamine) on monoaminergic and cholinergic systems in the rat brain have been well documented. However, little is known regarding the effects of MDMA on glutamatergic systems in the brain. In the present study the effects of multiple injections of MDMA on extracellular concentrations of glutamate in the striatum, prefrontal cortex, and dorsal hippocampus were examined. Two or four, but not one, injections of MDMA (10 mg/kg, i.p. at 2 h intervals) resulted in a 2–3 fold increase in the extracellular concentration of glutamate in the hippocampus; no increase was evident in the striatum or prefrontal cortex. Reverse dialysis of MDMA (100 µM) into the hippocampus also elicited an increase in extracellular glutamate. Treatment with the 5-HT reuptake inhibitor fluoxetine prevented the increase in extracellular glutamate in the hippocampus following the systemic administration of MDMA, as did treatment with the serotonin 5-HT2A/C receptor antagonist ketanserin. Moreover, reverse dialysis of the sodium channel blocker tetrodotoxin did not prevent the increase in extracellular glutamate in the hippocampus. These data support the view that stimulation of 5-HT2A/2C receptors on non-neuronal cells by 5-HT released by MDMA promotes glutamate efflux in the hippocampus.
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影响因子：
4.7
作者：
MOGHADDAM, B
通讯作者：
MOGHADDAM, B
影响因子：
5.3
作者：
Madayag, Aric;Kau, Kristen S.;Baker, David A.
通讯作者：
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影响因子：
4.2
作者：
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通讯作者：
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2.9
作者：
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通讯作者：
YAMAMOTO, BK
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2.5
作者：
Jha, Shanker;Rajendran, Rajeev;Vaidya, Vidita A.
通讯作者：
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