Prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis.
Prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis.
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DOI：
10.1371/journal.pone.0081050
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Li K
中科院分区：
文献类型：
--
作者：
Liu S;Liu C;Min X;Ji Y;Wang N;Liu D;Cai J;Li K
Aldehyde dehydrogenase (ALDH) has recently been reported as a marker of cancer stem-like cells in ovarian cancer. However, the prognostic role of ALDH in ovarian cancer still remains controversial. In this study, we aimed to evaluate the association between the expression of ALDH and the outcome of ovarian cancer patients by performing a meta-analysis. We systematically searched for studies investigating the relationships between ALDH expression and outcome of ovarian cancer patients. Only articles in which ALDH expression was detected by immunohistochemical staining were included. A meta-analysis was performed to generate combined hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival (OS) and disease-free survival (DFS). A total of 1,258 patients from 7 studies (6 articles) were included in the analysis. Our results showed that high ALDH expression in patients with ovarian cancer was associated with poor prognosis in terms of Os (HR, 1.25; 95% CI, 1.07-1.47; P = 0.005) and DFS (HR, 1.58; 95% CI, 1.00-2.49; P = 0.052), though the difference for DFS was not statistically significant. In addition, there was no evidence of publication bias as suggested by Begg’s and Egger’s tests (Begg’s test, P = 0.707; Egger’s test, P = 0.355). The present meta-analysis indicated that elevated ALDH expression was associated with poor prognosis in patients with ovarian cancer.
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影响因子：
11.2
作者：
Huang EH;Hynes MJ;Zhang T;Ginestier C;Dontu G;Appelman H;Fields JZ;Wicha MS;Boman BM
通讯作者：
Boman BM
影响因子：
5.7
作者：
Rahadiani, Nur;Ikeda, Jun-ichiro;Morii, Eiichi
通讯作者：
Morii, Eiichi
影响因子：
3.7
作者：
Deng S;Yang X;Lassus H;Liang S;Kaur S;Ye Q;Li C;Wang LP;Roby KF;Orsulic S;Connolly DC;Zhang Y;Montone K;Bützow R;Coukos G;Zhang L
通讯作者：
Zhang L
影响因子：
5.2
作者：
Luo, Yuchun;Dallaglio, Katiuscia;Chen, Ying;Robinson, William A.;Robinson, Steven E.;McCarter, Martin D.;Wang, Jianbin;Gonzalez, Rene;Thompson, David C.;Norris, David A.;Roop, Dennis R.;Vasiliou, Vasilis;Fujita, Mayumi
通讯作者：
Fujita, Mayumi
影响因子：
105.7
作者：
Higgins, JPT;Thompson, SG;Altman, DG
通讯作者：
Altman, DG