Pharmacokinetic studies of 1α, 24(R)-(OH)2D3 (TV-02) (1) Plasma level, distribution metabolism and excretion after a single subcutaneous administration to rats.
Pharmacokinetic studies of 1α, 24(R)-(OH)2D3 (TV-02) (1) Plasma level, distribution metabolism and excretion after a single subcutaneous administration to rats.
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1α, 24(R)-(OH)2D3 (TV-02) 的药代动力学研究 (1) 大鼠单次皮下注射后的血浆水平、分布代谢和排泄。
DOI：
10.2133/dmpk.5.3
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发表时间：
1990
影响因子：
2.1
通讯作者：
Tatsuyuki Maruchi
中科院分区：
文献类型：
--
作者：
T. Ohta;Yoshinori Takada;H. Mimura;Masaru Yamamoto;T. Matsunaga;M. Kiyoki;T. Ohba;Tatsuyuki Maruchi
3 H-TV-02的血浆特征、组织分布和排泄[1β-3H]-1 α，24（R）-（OH）_2D_3）在大鼠体内的变化血浆脂质提取物中的放射性由原型TV-02和少量1，24（R），25-（OH）3D 3，其维生素D3样活性弱于TV-02。第21次给药后的最大血浆放射性水平约为第7次给药后的1.5倍，几乎等于单次给药。原型TV-02迅速从注射部位（肝脏）消除，第21次给药后，小肠和脂肪组织中的放射性水平高于血浆中的放射性水平，尿液和粪便排泄量占10.8% 21次重复给药时和给药后的总放射性剂量分别为87.6%。
Plasma profiles, tissue distribution and excretion of 3H-TV-02 ([1β-3H]-1 α, 24(R)-(OH)2D3) were investigated in rats after repeated subcutaneous adm inistration (7 or 2ltimes) at the dose of 0.4μg/kg/day.The radioactivity in lipid extracts from plasma consisted of unchanged TV-02 and small amounts of 1, 24(R), 25-(OH)3D3 whose vitamin D3-like activity was weaker than that of TV-02. The maximal plasma levels of radioactivity following administration of the 21st dose were about 1.5times higher after 7 th dose and nearly equal to a single dose.The unchanged TV-02 was rapidly eliminatdd from the injection site, liver, small intestine and adipose tissue in which the levels of radioactivity were higher than in plasma after 21st administration.Urinary and fecal excretion amounted to 10.8% and 87.6% of the total dose of radioactivity during and after 2ltimes repeated administration, respectively.
大鼠胆汁中 1 α, 25-二羟基维生素 D3 的代谢物。
影响因子：
2.9
作者：
Onisko,BL;Esvelt,RP;Schnoes,HK;DeLuca,HF
通讯作者：
DeLuca,HF
大鼠皮肤中 1,25-二羟基维生素 D3 受体样蛋白的表征。
DOI：
10.1073/pnas.77.10.5822
发表时间：
1980
影响因子：
11.1
作者：
Simpson,RU;DeLuca,HF
通讯作者：
DeLuca,HF