Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics.
Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics.
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DOI：
10.1007/s00249-016-1142-1
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发表时间：
2016-10
影响因子：
2
通讯作者：
Beech, David J.
中科院分区：
文献类型：
--
作者：
Gaunt, Hannah J.;Vasudev, Naveen S.;Beech, David J.
关键词：
迫切需要新的癌症治疗方法。一种方法可能是靶向介导Ca2+进入的离子通道，因为Ca2+在包括癌细胞在内的许多细胞类型中起着关键作用。这些离子通道有几种类型，但在这里我们讨论由瞬时受体电位规范（TRPC）蛋白组装形成的离子通道，特别是那些涉及两个密切相关的家族成员：TRPC4和TRPC5的离子通道。我们之所以关注这些蛋白，是因为最近的研究指出了它们在癌症的重要方面的作用：耐药、通过细胞外囊泡的耐药传播、肿瘤血管化以及TRPC4/5通道激活剂(−)-englerin a引起的癌细胞死亡。我们得出结论，在这些蛋白被认为是抗癌细胞药物发现计划的强靶点之前，进一步的研究是合理的和必要的。然而，已经很明显的是，通道抑制剂不太可能引起显著的不良反应，相反，在癌症和化疗的背景下，可能有其他有益的作用，可能包括抑制先天恐惧、内脏疼痛和病理性心脏重塑。
Novel approaches towards cancer therapy are urgently needed. One approach might be to target ion channels mediating Ca2+ entry because of the critical roles played by Ca2+ in many cell types, including cancer cells. There are several types of these ion channels, but here we address those formed by assembly of transient receptor potential canonical (TRPC) proteins, particularly those which involve two closely related members of the family: TRPC4 and TRPC5. We focus on these proteins because recent studies point to roles in important aspects of cancer: drug resistance, transmission of drug resistance through extracellular vesicles, tumour vascularisation, and evoked cancer cell death by the TRPC4/5 channel activator (−)-englerin A. We conclude that further research is both justified and necessary before these proteins can be considered as strong targets for anti-cancer cell drug discovery programmes. It is nevertheless already apparent that inhibitors of the channels would be unlikely to cause significant adverse effects, but, rather, have other effects which may be beneficial in the context of cancer and chemotherapy, potentially including suppression of innate fear, visceral pain and pathological cardiac remodelling.
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影响因子：
3.7
作者：
Jiang HN;Zeng B;Zhang Y;Daskoulidou N;Fan H;Qu JM;Xu SZ
通讯作者：
Xu SZ
DOI：
10.1002/anie.201411511
发表时间：
2015-03-16
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Akbulut Y;Gaunt HJ;Muraki K;Ludlow MJ;Amer MS;Bruns A;Vasudev NS;Radtke L;Willot M;Hahn S;Seitz T;Ziegler S;Christmann M;Beech DJ;Waldmann H
通讯作者：
Waldmann H
DOI：
10.1161/atvbaha.110.205666
发表时间：
2010-07
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Al-Shawaf E;Naylor J;Taylor H;Riches K;Milligan CJ;O'Regan D;Porter KE;Li J;Beech DJ
通讯作者：
Beech DJ
影响因子：
4.8
作者：
Antigny, Fabrice;Girardin, Nathalie;Frieden, Maud
通讯作者：
Frieden, Maud
DOI：
10.1161/atvbaha.109.196584
发表时间：
2010-04-01
影响因子：
8.7
作者：
Ma, Xin;Qiu, Shuang;Yao, Xiaoqiang
通讯作者：
Yao, Xiaoqiang