Progesterone and its receptor signaling in cervical remodeling: Mechanisms of physiological actions and therapeutic implications.
Progesterone and its receptor signaling in cervical remodeling: Mechanisms of physiological actions and therapeutic implications.
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DOI：
10.1016/j.jsbmb.2022.106137
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发表时间：
2022-10
影响因子：
4.1
通讯作者：
Mahendroo, Mala
中科院分区：
文献类型：
--
作者：
Tripathy, Sudeshna;Nallasamy, Shanmugasundaram;Mahendroo, Mala
关键词：
子宫颈从闭合的刚性结构重塑，可以通过一系列复杂的分子事件来实现足够开放的刚性结构，该结构在很大程度上受到类固醇激素的孕酮和雌激素的调节而实现。在激素影响中，孕酮在大多数妊娠中发挥了主要作用，以启动组织强度的损失，但在称为软化的阶段中保持能力。同样重要的是消除孕妇在妊娠晚期功能的分子事件，从而允许在宫颈成熟和扩张期间失去组织能力和强度。在这篇综述中，我们关注当前的理解，孕酮受体信号在大多数怀孕中，然后在怀孕结束时孕酮受体作用丧失/转移，从而共同确保宫颈重塑作为成功分娩的必要条件。
The remodeling of the cervix from a closed rigid structure to one that can open sufficiently for passage of a term infant is achieved by a complex series of molecular events that in large part are regulated by the steroid hormones progesterone and estrogen. Among hormonal influences, progesterone exerts a dominant role for most of pregnancy to initiate a loss of tissue strength yet maintain competence in a phase termed softening. Equally important are the molecular events that abrogate progesterone function in late pregnancy to allow a loss of tissue competence and strength during cervical ripening and dilation. In this review, we focus on current understanding by which progesterone receptor signaling for the majority of pregnancy followed by a loss/shift in progesterone receptor action at the end of pregnancy, collectively ensure cervical remodeling as necessary for successful parturition.
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