Antidepressant medication use, weight gain, and risk of type 2 diabetes: a population-based study.
Antidepressant medication use, weight gain, and risk of type 2 diabetes: a population-based study.
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DOI：
10.2337/dc10-1187
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发表时间：
2010-12
期刊：
影响因子：
16.2
通讯作者：
Vahtera J
中科院分区：
文献类型：
--
作者：
Kivimäki M;Hamer M;Batty GD;Geddes JR;Tabak AG;Pentti J;Virtanen M;Vahtera J
To examine antidepressant medication use as a risk factor for type 2 diabetes and weight gain. A series of nested studies within a prospective cohort of 151,347 working-aged men and women including 9,197 participants with continuing antidepressant medication, 224 with severe depression, and 851 with incident type 2 diabetes during a mean follow-up of 4.8 years, as indicated by national health and prescription registers (the Public Sector study, Finland 1995–2005). In the first analysis, the case subjects were individuals with incident type 2 diabetes compared with matched diabetes-free control subjects. Antidepressant use of ≥200 defined daily doses was associated with a doubling of diabetes risk in both participants with no indication of severe depression (odds ratio 1.93 [95% CI 1.48–2.51]) and participants with severe depression (2.65 [1.31–5.39]). In further analyses, the exposed group was antidepressant users and the reference group was nonusers matched for depression-related characteristics. The 5-year absolute risk of diabetes was 1.1% for nonusers, 1.7% for individuals treated with 200–399 defined daily doses a year, and 2.3% for those with ≥400 defined daily doses (Ptrend < 0.0001). An average self-reported weight gain, based on repeated surveys, was 1.4 kg (2.5%) among nonusers and 2.5 kg (4.3%) among users of ≥200 defined daily doses (Ptrend < 0.0001). Separate analyses for tricyclic antidepressants and selective serotonin reuptake inhibitors replicated these findings. In these data, continuing use of antidepressant medication was associated with an increased relative risk of type 2 diabetes, although the elevation in absolute risk was modest.
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影响因子：
16.2
作者：
Kivimäki M;Tabák AG;Lawlor DA;Batty GD;Singh-Manoux A;Jokela M;Virtanen M;Salo P;Oksanen T;Pentti J;Witte DR;Vahtera J
通讯作者：
Vahtera J
影响因子：
3.3
作者：
Lustman, PJ;Griffith, LS;McGill, JB
通讯作者：
McGill, JB
影响因子：
17.7
作者：
Andersohn, Frank;Schade, Rene;Garbe, Edeltraut
通讯作者：
Garbe, Edeltraut
影响因子：
15.8
作者：
Kirsch, Irving;Deacon, Brett J.;Huedo-Medina, Tania B.;Scoboria, Alan;Moore, Thomas J.;Johnson, Blair T.
通讯作者：
Johnson, Blair T.
影响因子：
2.9
作者：
Derijks, Hieronymus J.;Meyboom, Ronald H. B.;Heerdink, Eibert R.;De Koning, Fred H. P.;Janknegt, Rob;Lindquist, Marie;Egberts, Antoine C. G.
通讯作者：
Egberts, Antoine C. G.