Antidepressant use before and after the diagnosis of type 2 diabetes: a longitudinal modeling study.
Antidepressant use before and after the diagnosis of type 2 diabetes: a longitudinal modeling study.
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DOI：
10.2337/dc09-2359
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发表时间：
2010-07
期刊：
影响因子：
16.2
通讯作者：
Vahtera J
中科院分区：
文献类型：
--
作者：
Kivimäki M;Tabák AG;Lawlor DA;Batty GD;Singh-Manoux A;Jokela M;Virtanen M;Salo P;Oksanen T;Pentti J;Witte DR;Vahtera J
检查糖尿病诊断前后抗抑郁药的使用情况。这项研究是对糖尿病和非糖尿病人群的纵向分析，这些人群选自芬兰151，618名男性和女性的前瞻性队列研究（芬兰公共部门研究，1995-2005）。我们分析了493名2型糖尿病患者和2,450名匹配的非糖尿病对照受试者在诊断前4年和诊断后4年期间每年使用抗抑郁药的情况。为了比较，我们对748名癌症患者和3,730名匹配的对照组进行了相应的分析。在多水平纵向模型中，糖尿病患者使用抗抑郁药的优势比是非糖尿病患者的2.00倍（95%CI 1.57-2.55）。除了在诊断当年抗抑郁药使用的暂时峰值（OR 2.66 [95% CI 1.94-3.65]）外，这些组之间在糖尿病诊断前后抗抑郁药使用的相对差异相似。在偶发癌症病例受试者中，癌症诊断后抗抑郁药的使用大幅增加，表明我们的分析对于检测抗抑郁药轨迹的长期变化是敏感的。2型糖尿病的诊断意识可能会暂时增加抑郁症状的风险。需要进一步的研究来确定在糖尿病诊断前更普遍使用抗抑郁药是否与抑郁症的影响，抗抑郁药使用的副作用或抑郁症和糖尿病的共同因果关系有关。
To examine antidepressant use before and after the diagnosis of diabetes. This study was a longitudinal analysis of diabetic and nondiabetic groups selected from a prospective cohort study of 151,618 men and women in Finland (the Finnish Public Sector Study, 1995–2005). We analyzed the use of antidepressants in those 493 individuals who developed type 2 diabetes and their 2,450 matched nondiabetic control subjects for each year during a period covering 4 years before and 4 years after the diagnosis. For comparison, we undertook a corresponding analysis on 748 individuals who developed cancer and their 3,730 matched control subjects. In multilevel longitudinal models, the odds ratio for antidepressant use in those who developed diabetes was 2.00 (95% CI 1.57–2.55) times greater than that in nondiabetic subjects. The relative difference in antidepressant use between these groups was similar before and after the diabetes diagnosis except for a temporary peak in antidepressant use at the year of the diagnosis (OR 2.66 [95% CI 1.94–3.65]). In incident cancer case subjects, antidepressant use substantially increased after the cancer diagnosis, demonstrating that our analysis was sensitive for detecting long-term changes in antidepressant trajectories when they existed. Awareness of the diagnosis of type 2 diabetes may temporarily increase the risk of depressive symptoms. Further research is needed to determine whether more prevalent use of antidepressants noted before the diagnosis of diabetes relates to effects of depression, side effects of antidepressant use, or a common causal pathway for depression and diabetes.
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影响因子：
16.2
作者：
de Lauzon-Guillain B;Balkau B;Charles MA;Romieu I;Boutron-Ruault MC;Clavel-Chapelon F
通讯作者：
Clavel-Chapelon F
影响因子：
3.3
作者：
Lustman, PJ;Griffith, LS;McGill, JB
通讯作者：
McGill, JB
影响因子：
8
作者：
Thomas, Claudia;Hyppoenen, Elina;Power, Chris
通讯作者：
Power, Chris
影响因子：
120.7
作者：
DEROGATIS, LR;MORROW, GR;CARNICKE, CLM
通讯作者：
CARNICKE, CLM
影响因子：
8.2
作者：
Knol, MJ;Twisk, JWR;Pouwer, F
通讯作者：
Pouwer, F