Function of peripheral nerves in the development and healing of tendon and bone.
Function of peripheral nerves in the development and healing of tendon and bone.
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DOI：
10.1016/j.semcdb.2021.05.001
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发表时间：
2022-03
影响因子：
7.3
通讯作者：
Tomlinson RE
中科院分区：
文献类型：
--
作者：
Rajpar I;Tomlinson RE
虽然周围神经系统在全身稳态和感觉中的功能已被了解多年，但最近的研究发现了神经支配在肌肉骨骼系统中的新作用。本文综述了神经在肌腱和骨这两种相连组织的发育和修复中的作用。健康肌腱的神经支配通常局限于腱鞘，肌腱-骨附着单位通常是神经性的。与肌腱相反，骨是受神经支配和血管化的结构。从历史上看，骨骼中丰富的外周神经的功能仅限于疾病和损伤中的疼痛和一些非疼痛的感觉知觉。事实上，我们对肌腱、骨骼和附着点中周围神经的了解大多局限于健康和受伤组织中神经支配的来源和类型。然而，最近的研究对胚胎和出生后发育期间以及对损伤的反应中神经的外观、类型和神经支配模式进行了重要的观察，这表明周围神经在肌肉骨骼组织的形成中具有更广泛的作用。事实上，肌腱和骨骼在胚胎中胚层中以密切的时空关系发育。肢体去神经支配的模型已经阐明了感觉神经支配在骨骼中的重要性，在较小程度上，肌腱发育，最近的工作已经解开了关键的神经信号通路。此外，感觉神经支配的丧失也会损害骨折的愈合，并可能导致慢性肌腱病。然而，需要更多的研究来将我们对周围神经的认识转化为治疗骨和肌腱疾病的治疗策略。
Although the functions of the peripheral nervous system in whole body homeostasis and sensation have been understood for many years, recent investigation has uncovered new roles for innervation in the musculoskeletal system. This review centers on advances regarding the function of nerves in the development and repair of two connected tissues: tendon and bone. Innervation in healthy tendons is generally confined to the tendon sheaths, and tendon-bone attachment units are typically aneural. In contrast to tendon, bone is an innervated and vascularized structure. Historically, the function of abundant peripheral nerves in bone has been limited to pain and some non-painful sensory perception in disease and injury. Indeed, much of our understanding of peripheral nerves in tendons, bones, and entheses is limited to the source and type of innervation in healthy and injured tissues. However, more recent studies have made important observations regarding the appearance, type, and innervation patterns of nerves during embryonic and postnatal development and in response to injury, which suggest a more expansive role for peripheral nerves in the formation of musculoskeletal tissues. Indeed, tendons and bones develop in a close spatiotemporal relationship in the embryonic mesoderm. Models of limb denervation have shed light on the importance of sensory innervation in bone and to a lesser extent, tendon development, and more recent work has unraveled key nerve signaling pathways. Furthermore, loss of sensory innervation also impairs healing of bone fractures and may contribute to chronic tendinopathy. However, more study is required to translate our knowledge of peripheral nerves to therapeutic strategies to combat bone and tendon diseases.
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影响因子：
11.1
作者：
Appelt, Jessika;Baranowsky, Anke;Keller, Johannes
通讯作者：
Keller, Johannes
影响因子：
2.8
作者：
Ackermann, PW;Ahmed, M;Kreicbergs, A
通讯作者：
Kreicbergs, A
II型糖尿病大鼠模型中肌腱愈合期间的神经营养和血管生成能力受损。
影响因子：
3.7
作者：
Ahmed AS;Li J;Abdul AM;Ahmed M;Östenson CG;Salo PT;Hewitt C;Hart DA;Ackermann PW
通讯作者：
Ackermann PW
影响因子：
3.3
作者：
Castañeda-Corral G;Jimenez-Andrade JM;Bloom AP;Taylor RN;Mantyh WG;Kaczmarska MJ;Ghilardi JR;Mantyh PW
通讯作者：
Mantyh PW
影响因子：
4.1
作者：
Berendsen AD;Olsen BR
通讯作者：
Olsen BR