Effect of CXCL12/CXCR4 signaling on neuropathic pain after chronic compression of dorsal root ganglion.
Effect of CXCL12/CXCR4 signaling on neuropathic pain after chronic compression of dorsal root ganglion.
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DOI：
10.1038/s41598-017-05954-1
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发表时间：
2017-07-18
影响因子：
4.6
通讯作者：
Fan N
中科院分区：
文献类型：
--
作者：
Yu Y;Huang X;Di Y;Qu L;Fan N
Neuropathic pain is a complex, chronic pain state that often accompanies tissue damage, inflammation or injury of the nervous system. However the underlying molecular mechanisms still remain unclear. Here, we showed that CXCL12 and CXCR4 were upregulated in the dorsal root ganglion (DRG) after chronic compression of DRG (CCD), and some CXCR4 immunopositive neurons were also immunopositive for the nociceptive neuronal markers IB4, TRPV1, CGRP, and substance P. The incidence and amplitude of CXCL12-induced Ca2+ response in primary sensory neurons from CCD mice was significantly increased compared to those from control animals. CXCL12 depolarized the resting membrane potential, decreased the rheobase, and increased the number of action potentials evoked by a depolarizing current at 2X rheobase in neurons from CCD mice. The mechanical and thermal hypernociception after CCD was attenuated by administration of a CXCR4 antagonist AMD3100. These findings suggest that CXCL12/CXCR4 signaling contributes to hypernociception after CCD, and targeting CXCL12/CXCR4 signaling pathway may alleviate neuropathic pain.
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DOI：
10.1523/jneurosci.5053-10.2011
发表时间：
2011-03-09
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gemes G;Bangaru ML;Wu HE;Tang Q;Weihrauch D;Koopmeiners AS;Cruikshank JM;Kwok WM;Hogan QH
通讯作者：
Hogan QH
影响因子：
7.4
作者：
Hu, SJ;Xing, JL
通讯作者：
Xing, JL
影响因子：
2.8
作者：
Knerlich-Lukoschus, Friederike;von der Ropp-Brenner, Beata;Held-Feindt, Janka
通讯作者：
Held-Feindt, Janka
影响因子：
3.3
作者：
Menichella DM;Abdelhak B;Ren D;Shum A;Frietag C;Miller RJ
通讯作者：
Miller RJ
影响因子：
13.9
作者：
Costigan M;Scholz J;Woolf CJ
通讯作者：
Woolf CJ