Uncovering the mystery of gliding motility in the myxobacteria.

Uncovering the mystery of gliding motility in the myxobacteria.
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DOI:
10.1146/annurev-genet-110410-132547
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发表时间:
2011
影响因子:
11.1
通讯作者:
Zusman DR
Zusman DR
中科院分区:
生物学1区
文献类型:
--
作者:
Nan B;Zusman DR

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细菌的滑动运动是细胞在固体表面上不受鞭毛或皮利帮助的平滑运动。许多不同的细菌群体都表现出滑翔运动,但自从世纪前首次观察到滑翔运动的机制以来,它一直是一个谜。最近的研究粘球菌xanthus,土壤粘细菌的运动,提出了一个可能的机制,在这种生物体的滑行。大约四十米。Xanthus基因被证明参与滑行运动,并且它们的一些蛋白产物被标记并定位在细胞内。这些研究表明,M. Xanthus涉及大的多蛋白质结构复合物、调节蛋白和细胞骨架丝。在这篇综述中,我们总结了最近的实验,提供了这个新兴的观点M的基础。运动性我们还讨论了滑翔的替代模型。
Bacterial gliding motility is the smooth movement of cells on solid surfaces unaided by flagella or pili. Many diverse groups of bacteria exhibit gliding, but the mechanism of gliding motility has remained a mystery since it was first observed more than a century ago. Recent studies on the motility of Myxococcus xanthus, a soil myxobacterium, suggest a likely mechanism for gliding in this organism. About forty M. xanthus genes were shown to be involved in gliding motility, and some of their protein products were labeled and localized within cells. These studies suggest that gliding motility in M. xanthus involves large multiprotein structural complexes, regulatory proteins, and cytoskeletal filaments. In this review, we summarize recent experiments that provide the basis for this emerging view of M. xanthus motility. We also discuss alternative models for gliding.
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