Development of vascular disease models to explore disease causation and pathomechanisms of rare vascular diseases.
Development of vascular disease models to explore disease causation and pathomechanisms of rare vascular diseases.
复制标题
DOI：
10.1007/s00281-022-00925-9
复制
发表时间：
2022-05
影响因子：
9
通讯作者：
Boehm M
中科院分区：
文献类型：
--
作者：
Harper RL;Ferrante EA;Boehm M
随着下一代测序（NGS）和生物打印和生物材料开发等集成技术的新时代的到来，医学领域正在努力向前发展，罕见的单基因血管疾病建模在这一领域的应用开始出现。凭借其遗传简单性和更广泛的适用性，这些患者特异性模型处于现代个性化医疗的最前沿。作为一个整体，罕见疾病是全球医疗保健系统的重大负担，而罕见血管疾病在其中占很大比例。费用高是由于诊断过程漫长，影响到从婴儿到成人的所有年龄段，以及疾病的严重性和慢性性质。其复杂性需要复杂的疾病模型和涉及多学科团队的综合方法。在这里，我们回顾这些新兴的血管疾病模型，它们如何有助于我们了解罕见血管疾病的病理机制，并为治疗发现提供有用的平台。
As the field of medicine is striving forward heralded by a new era of next-generation sequencing (NGS) and integrated technologies such as bioprinting and biological material development, the utility of rare monogenetic vascular disease modeling in this landscape is starting to emerge. With their genetic simplicity and broader applicability, these patient-specific models are at the forefront of modern personalized medicine. As a collective, rare diseases are a significant burden on global healthcare systems, and rare vascular diseases make up a significant proportion of this. High costs are due to a lengthy diagnostic process, affecting all ages from infants to adults, as well as the severity and chronic nature of the disease. Their complex nature requires sophisticated disease models and integrated approaches involving multidisciplinary teams. Here, we review these emerging vascular disease models, how they contribute to our understanding of the pathomechanisms in rare vascular diseases and provide useful platforms for therapeutic discovery.
登录
查看更多内容
影响因子：
4.1
作者：
Fernandez-Marmiesse A;Gouveia S;Couce ML
通讯作者：
Couce ML
影响因子：
14
作者：
Gold K;Gaharwar AK;Jain A
通讯作者：
Jain A
DOI：
10.1074/jbc.m113.495531
发表时间：
2014-02-07
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Di Bernardini E;Campagnolo P;Margariti A;Zampetaki A;Karamariti E;Hu Y;Xu Q
通讯作者：
Xu Q
影响因子：
37.8
作者：
Hong KH;Lee YJ;Lee E;Park SO;Han C;Beppu H;Li E;Raizada MK;Bloch KD;Oh SP
通讯作者：
Oh SP
影响因子：
23.9
作者：
Gu M;Shao NY;Sa S;Li D;Termglinchan V;Ameen M;Karakikes I;Sosa G;Grubert F;Lee J;Cao A;Taylor S;Ma Y;Zhao Z;Chappell J;Hamid R;Austin ED;Gold JD;Wu JC;Snyder MP;Rabinovitch M
通讯作者：
Rabinovitch M