Emerging trends in multiscale modeling of vascular pathophysiology: Organ-on-a-chip and 3D printing.
Emerging trends in multiscale modeling of vascular pathophysiology: Organ-on-a-chip and 3D printing.
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DOI：
10.1016/j.biomaterials.2018.07.029
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发表时间：
2019-03
期刊：
影响因子：
14
通讯作者：
Jain A
中科院分区：
文献类型：
--
作者：
Gold K;Gaharwar AK;Jain A
大多数人类血管系统的生物医学和药物研究旨在揭示驱动疾病从分子水平到器官水平进展的复杂机制。获得的知识可以用于创新诊断和治疗策略，最终可以为患者精确确定。尽管取得了重大进展，但当前的建模策略通常仅限于识别、量化和剖析调节人类血管疾病的特定细胞和分子靶标。因此，需要开发多尺度建模方法，以提高我们的知识并促进下一代血管疾病治疗方法的设计。本文批判性地回顾了目前用于模拟血管疾病的动物模型、静态体外系统和动态体外培养系统。书中重点强调了新兴方法的潜力，特别是器官芯片和三维 (3D) 打印，以概括人类固有的血管生理学和解剖学。还介绍了这些方法的应用以及在设计和筛选新疗法方面的未来展望。
Most biomedical and pharmaceutical research of the human vascular system aims to unravel the complex mechanisms which drive disease progression from molecular to organ levels. The knowledge gained can then be used to innovate diagnostic and treatment strategies that can ultimately be determined precisely for patients. Despite major advancements, current modeling strategies are often limited at identifying, quantifying, and dissecting specific cellular and molecular targets that regulate human vascular diseases. Therefore, development of multiscale modeling approaches is needed that can advance our knowledge and facilitate the design of nextgeneration therapeutic approaches in vascular diseases. This article critically reviews animal models, static in vitro systems, and dynamic in vitro culture systems currently used to model vascular diseases. A leading emphasis on the potential of emerging approaches, specifically organ-on-a-chip and three-dimensional (3D) printing, to recapitulate the innate human vascular physiology and anatomy is described. The applications of these approaches and future outlook in designing and screening novel therapeutics is also presented.
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影响因子：
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作者：
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DOI：
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发表时间：
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DOI：
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发表时间：
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期刊：
Nanomedicine : nanotechnology, biology, and medicine
影响因子：
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作者：
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通讯作者：
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