Bystanders or not? Microglia and lymphocytes in aging and stroke.
Bystanders or not? Microglia and lymphocytes in aging and stroke.
复制标题
是否旁观者？衰老和中风中的小胶质细胞和淋巴细胞。
DOI：
10.4103/1673-5374.360345
复制
发表时间：
2023-07
影响因子：
6.1
通讯作者：
Chauhan A
中科院分区：
文献类型：
--
作者：
Nguyen JN;Chauhan A
随着世界人口平均年龄的增加，更多的人将面临与衰老相关的衰弱疾病，包括痴呆和中风。这些疾病的发生率不仅随着年龄的增长而增加，而且老年患者术后的恢复往往更差。研究人员和卫生专业人员必须揭示并了解与年龄相关的疾病背后的因素，以便为老年患者开发治疗方法。衰老会导致免疫系统发生深刻的变化，包括大脑中小胶质细胞的激活。激活的小胶质细胞促进 T 淋巴细胞迁移，导致老年人和啮齿动物的神经炎症、白质损伤和认知障碍增加。在衰老的大脑中观察到 T 和 B 淋巴细胞的存在，并且与更糟糕的中风结果相关。中风的临床前策略针对小胶质细胞或淋巴细胞或它们之间的通讯，以促进老年受试者的功能恢复。在这篇综述中，我们研究了小胶质细胞、T 淋巴细胞和 B 淋巴细胞在衰老中的作用以及它们如何导致认知障碍。此外，我们提供了有关这些细胞的贡献及其在临床前老年中风中相互作用的重要更新。
As the average age of the world population increases, more people will face debilitating aging-associated conditions, including dementia and stroke. Not only does the incidence of these conditions increase with age, but the recovery afterward is often worse in older patients. Researchers and health professionals must unveil and understand the factors behind age-associated diseases to develop a therapy for older patients. Aging causes profound changes in the immune system including the activation of microglia in the brain. Activated microglia promote T lymphocyte transmigration leading to an increase in neuroinflammation, white matter damage, and cognitive impairment in both older humans and rodents. The presence of T and B lymphocytes is observed in the aged brain and correlates with worse stroke outcomes. Preclinical strategies in stroke target either microglia or the lymphocytes or the communications between them to promote functional recovery in aged subjects. In this review, we examine the role of the microglia and T and B lymphocytes in aging and how they contribute to cognitive impairment. Additionally, we provide an important update on the contribution of these cells and their interactions in preclinical aged stroke.
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影响因子：
13.6
作者：
Da Mesquita S;Herz J;Wall M;Dykstra T;de Lima KA;Norris GT;Dabhi N;Kennedy T;Baker W;Kipnis J
通讯作者：
Kipnis J
影响因子：
3.6
作者：
Dziennis, Suzan;Mader, Sarah;Akiyoshi, Kozaburo;Ren, Xuefang;Ayala, Patricia;Burrows, Gregory G.;Vandenbark, Arthur A.;Herson, Paco S.;Hurn, Patricia D.;Offner, Halina A.
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Offner, Halina A.
影响因子：
4.8
作者：
Buga AM;Margaritescu C;Scholz CJ;Radu E;Zelenak C;Popa-Wagner A
通讯作者：
Popa-Wagner A
影响因子：
6.9
作者：
Akiyoshi, Kozaburo;Dziennis, Suzan;Hurn, Patricia D.
通讯作者：
Hurn, Patricia D.
影响因子：
3.3
作者：
Becker KJ;Tanzi P;Zierath D;Buckwalter MS
通讯作者：
Buckwalter MS