Sex differences in cholinergic analgesia II: differing mechanisms in two models of allodynia.
Sex differences in cholinergic analgesia II: differing mechanisms in two models of allodynia.
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胆碱能镇痛的性别差异II：两种异常性疼痛模型的不同机制。
DOI：
10.1097/00000542-199911000-00039
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发表时间：
1999
期刊：
影响因子：
8.8
通讯作者：
Eisenach,JC
中科院分区：
文献类型：
--
作者：
Lavand'homme,PM;Eisenach,JC
背景胆碱能药物可减轻动物神经损伤后的痛觉过敏，可用于神经病理性疼痛的治疗。鞘内注射新斯的明和神经烟碱激动剂对急性热伤害性刺激的雌性大鼠比雄性大鼠更有效。本研究旨在探讨鞘内拟胆碱类药物在两种痛觉过敏模型中的抗痛觉过敏作用是否也存在性别差异，并探讨其药理机制。方法鞘内留置导管的雌雄大鼠分别注射新斯的明、比妥英钠(M受体激动剂)、RJR-2403(神经元烟碱受体激动剂)或与阿托品(M受体拮抗剂)、甲氨基甲胺(烟碱受体拮抗剂)、酚妥拉明(α-肾上腺素能拮抗剂)或生理盐水联合注射。结果新斯的明和RJR-2403对大鼠神经损伤后痛觉超敏的抑制作用强于雄鼠，而新斯的明和RJR-2403的作用强于雄鼠，拮抗剂研究也符合烟碱类成分对这种性别差异的解释。酚妥拉明不能逆转新斯的明的作用。相反，在辣椒素诱导的痛觉过敏中，新斯的明加甲壳胺，而不是新斯的明或RJR-2403在雌性大鼠中比雄性大鼠更有效。结论神经损伤后鞘内注射新斯的明的作用类似于接受急性伤害性热刺激的正常动物的性别差异。然而，这种性别差异并不适用于所有的疼痛模型，因为这种性别差异在皮内注射辣椒素后并不存在，它与脊髓去甲肾上腺素能机制的相互作用也不是在所有模型中都是一致的。
BackgroundCholinergic agents reduce allodynia after nerve injury in animals and may be useful in the treatment of neuropathic pain. Intrathecally administered neostigmine and neuronal nicotinic agonists are more potent in female than in male rats against acute thermal noxious stimuli. The purpose of this study was to determine whether there is also a sex difference in the antiallodynic effects of intrathecal cholinomimetic agents in two models of allodynia and to test their pharmacologic mechanisms.MethodsMale and female rats with indwelling intrathecal catheters received injections of neostigmine, bethanechol (muscarinic agonist), RJR-2403 (neuronal nicotinic agonist) alone or with atropine (muscarinic antagonist), mecamylamine (nicotinic antagonist), phentolamine (alpha-adrenergic antagonist), or saline control. The effect of these agents was determined on mechanical allodynia produced by either intraplantar injection of capsaicin or ligation of spinal nerves.ResultsNeostigmine and RJR-2403 but not bethanechol were more potent in female than in male rats in reducing allodynia after nerve injury, and antagonist studies were also consistent with a nicotinic component to explain this sex difference. Phentolamine did not reverse neostigmine's effect. In contrast, for capsaicin-induced allodynia, neostigmine plus mecamylamine but not neostigmine or RJR-2403 was more potent in female than in male rats.ConclusionsThese data demonstrate a sex difference of intrathecal neostigmine after nerve injury-induced allodynia similar to that observed in normal animals that received acute noxious thermal stimulation. However, this sex difference is not universal to all pain models because it was not present after intradermal capsaicin injection, nor is its interaction with spinal noradrenergic mechanisms consistent in all models.
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影响因子：
7.4
作者：
Gilchrist, HD;Allard, BL;Simone, DA
通讯作者：
Simone, DA
DOI：
--
发表时间：
1995
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
T. L. Yaksh;J. W. Pogrel;Youn-Woo Lee;S. Chaplan
通讯作者：
T. L. Yaksh;J. W. Pogrel;Youn-Woo Lee;S. Chaplan
通过大鼠体内脊髓微透析测量，鞘内烟碱激动剂引起兴奋性氨基酸的释放。
DOI：
--
发表时间：
1996
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Khan,IM;Marsala,M;Printz,MP;Taylor,P;Yaksh,TL
通讯作者：
Yaksh,TL
影响因子：
2.5
作者：
COYLE, DE;SEHLHORST, CS;MASCARI, C
通讯作者：
MASCARI, C
Epibatidine：烟碱乙酰胆碱受体激动剂释放单胺能神经递质：大鼠体外和体内证据。
影响因子：
3.5
作者：
Aida I. Sacaan;F. Menzaghi;J. Dunlop;Lucia Correa;Kevin T. Whelan;G. Lloyd
通讯作者：
G. Lloyd