Aging with HIV-1 Infection: Motor Functions, Cognition, and Attention--A Comparison with Parkinson's Disease.
Aging with HIV-1 Infection: Motor Functions, Cognition, and Attention--A Comparison with Parkinson's Disease.
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DOI：
10.1007/s11065-015-9305-x
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发表时间：
2015-12
影响因子：
5.8
通讯作者：
Schulte T
中科院分区：
文献类型：
--
作者：
DeVaughn S;Müller-Oehring EM;Markey B;Brontë-Stewart HM;Schulte T
最近在各种组合的高效抗逆转录病毒疗法（HAART）方面取得的进展大大延长了艾滋病毒感染者的预期寿命。被诊断为艾滋病毒感染者的年龄超过50岁，但正在经历艾滋病毒感染和衰老对大脑功能的累积影响。在HIV感染的老年个体中，免疫衰老和HIV病毒载量之间的潜在协同作用增加了对HIV相关脑损伤和功能性脑网络退化的易感性，类似于帕金森病（PD），这是老年人群中第二常见的神经退行性疾病。虽然这两种疾病的原发病理学存在明显的诊断差异，即，PD中黑质中多巴胺产生细胞的死亡和HIV中的神经炎症，对基底神经节（BG）中多巴胺能末梢的神经毒性已经暗示在HIV的发病机制中和PD的发病机制中的神经炎症。与PD类似，HIV感染影响BG的结构，BG是互连回路的一部分，包括将脑干核与BG和有助于注意力、认知控制和运动功能的皮质连接起来的中皮质边缘通路。本综述讨论了艾滋病病毒感染者的认知和运动功能与年龄相关的神经退行性过程相比，在PD老化和神经炎症的综合影响。尽管面临许多挑战，但一些HIV患者成功地变老，最有可能的是通过重新分配神经网络资源来增强功能，就像健康老年人一样;这种补偿可能会因新出现的PD而减少。
Recent advances in highly active anti-retroviral therapy (HAART) in their various combinations have dramatically increased the life expectancies of HIV-infected persons. People diagnosed with HIV are living beyond the age of 50 but are experiencing the cumulative effects of HIV infection and aging on brain function. In HIV-infected aging individuals, the potential synergy between immunosenescence and HIV viral loads increases susceptibility to HIV-related brain injury and functional brain network degradation similar to that seen in Parkinson’s disease (PD), the second most common neurodegenerative disorder in the aging population. Although there are clear diagnostic differences in the primary pathology of both diseases, i.e., death of dopamine-generating cells in the substantia nigra in PD and neuroinflammation in HIV, neurotoxicity to dopaminergic terminals in the basal ganglia (BG) has been implied in the pathogenesis of HIV and neuroinflammation in the pathogenesis of PD. Similar to PD, HIV infection affects structures of the BG, which are part of interconnected circuits including mesocorticolimbic pathways linking brainstem nuclei to BG and cortices subserving attention, cognitive control, and motor functions. The present review discusses the combined effects of aging and neuroinflammation in HIV individuals on cognition and motor function in comparison with age-related neurodegenerative processes in PD. Despite the many challenges, some HIV patients manage to age successfully, most likely by redistribution of neural network resources to enhance function, as occurs in healthy elderly; such compensation could be curtailed by emerging PD.
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影响因子：
11.2
作者：
Bhaskaran, Krishnan;Mussini, Cristina;Porter, Kholoud
通讯作者：
Porter, Kholoud
影响因子：
4
作者：
Aarsland, D;Hutchinson, M;Larsen, JP
通讯作者：
Larsen, JP
影响因子：
3.8
作者：
BUCHBINDER, SP;KATZ, MH;HOLMBERG, SD
通讯作者：
HOLMBERG, SD
DOI：
10.1097/qai.0b013e318249db17
发表时间：
2012-04-15
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Ances BM;Ortega M;Vaida F;Heaps J;Paul R
通讯作者：
Paul R
DOI：
10.1080/13803395.2012.692772
发表时间：
2012-01-01
影响因子：
2.2
作者：
Cattie, Jordan E.;Doyle, Katie;Woods, Steven Paul
通讯作者：
Woods, Steven Paul