Transient vitreous inflammatory reactions associated with combination antiretroviral therapy in patients with AIDS and cytomegalovirus retinitis.
Transient vitreous inflammatory reactions associated with combination antiretroviral therapy in patients with AIDS and cytomegalovirus retinitis.
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艾滋病和巨细胞病毒性视网膜炎患者与抗逆转录病毒联合治疗相关的短暂性玻璃体炎症反应。
DOI：
10.1016/s0002-9394(99)80134-2
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发表时间：
1998
影响因子：
4.2
通讯作者：
T. Margolis
中科院分区：
文献类型：
--
作者：
M. Zegans;R. Walton;G. Holland;James J. O'Donnell;M. Jacobson;M. Jacobson;T. Margolis
目的报道获得性免疫缺陷综合征（AIDS）、巨细胞病毒性视网膜炎患者在接受包括蛋白酶抑制剂在内的抗逆转录病毒治疗期间，其眼睛可能发生短暂的玻璃体炎症反应，CD4+ t淋巴细胞计数增加。方法回顾了8例艾滋病合并巨细胞病毒视网膜炎患者的病历，这些患者的玻璃体炎症反应大于该疾病的常见反应。结果所有患者玻璃体炎症反应均使后极视野模糊。无虹膜结节、粘连、青光眼、囊样黄斑水肿。6例单侧巨细胞病毒视网膜炎患者，炎症仅发生在巨细胞病毒视网膜炎的眼睛。6例患者的玻璃体炎症反应与临床无活动性巨细胞病毒视网膜炎相关，1例患者的疾病再激活，1例患者在诊断为活动性疾病时出现。细胞巨病毒视网膜炎在这些患者中没有复发，因为他们的玻璃体炎症发作。在联合抗逆转录病毒治疗导致CD4+ t淋巴细胞计数大幅增加后，所有8名患者均出现玻璃体炎症。5例患者发生玻璃体炎症反应时CD4+ t淋巴细胞计数大于100个/ μl。未发现其他引起葡萄膜炎的原因。结论艾滋病合并细胞巨病毒性视网膜炎患者联合抗逆转录病毒治疗可发生短暂性眼内炎症。我们认为这种炎症反应反映了对巨细胞病毒的免疫反应的改善。
PURPOSETo report the observation that a transient vitreous inflammatory reaction may develop in the eyes of patients with acquired immunodeficiency syndrome (AIDS), cytomegalovirus retinitis, and an increased CD4+T-lymphocyte count during treatment with antiretroviral therapy including a protease inhibitor.METHODSWe reviewed the medical records of eight patients with AIDS and cytomegalovirus retinitis who developed vitreous inflammatory reactions greater than those usually seen with this disease.RESULTSVitreous inflammatory reactions obscured the view of the posterior pole in all patients. No iris nodules, synechiae, glaucoma, or cystoid macular edema were observed. Six patients had unilateral cytomegalovirus retinitis, and, in each, the inflammation occurred only in the eye with cytomegalovirus retinitis. The vitreous inflammatory reactions were associated with clinically inactive cytomegalovirus retinitis in six patients, with disease reactivation in one patient, and were present at diagnosis of active disease in one patient. Cyto-megalovirus retinitis has not recurred in any of these patients since their episodes of vitreous inflammation. Vitreous inflammation developed in all eight patients after a substantial increase in CD4+T-lymphocyte counts caused by combination anti-retroviral therapy. Five patients had CD4+T-lymphocyte counts of greater than 100 cells per μl at the time the vitreous inflammatory reaction developed. No other causes of uveitis were found.CONCLUSIONSPatients with AIDS and cyto-megalovirus retinitis may develop transient intra-ocular inflammation associated with combination antiretroviral therapy. We believe that this inflammation reflects an improved immune response against cytomegalovirus.
用抗病毒药物更昔洛韦治疗后巨细胞病毒视网膜病的病理特征。
影响因子：
13.7
作者：
Pepose,JS;Newman,C;Bach,MC;Quinn,TC;Ambinder,RF;Holland,GN;Hodstrom,PS;Frey,HM;Foos,RY
通讯作者：
Foos,RY
影响因子：
13.7
作者：
G. Holland;G. Holland;J. Pepose;T. H. Pettit;T. H. Pettit;M. Gottlieb;R. Yee;R. Yee;R. Foos;R. Foos
通讯作者：
G. Holland;G. Holland;J. Pepose;T. H. Pettit;T. H. Pettit;M. Gottlieb;R. Yee;R. Yee;R. Foos;R. Foos
获得性免疫缺陷综合征患者中 CD4 计数与巨细胞病毒视网膜炎和人类免疫缺陷病毒相关非感染性视网膜血管病变患病率之间的相关性。
影响因子：
4.2
作者：
Kuppermann,BD;Petty,JG;Richman,DD;Mathews,WC;Fullerton,SC;Rickman,LS;Freeman,WR
通讯作者：
Freeman,WR