Intestinal Stem Cells and Immune Cell Relationships: Potential Therapeutic Targets for Inflammatory Bowel Diseases.
Intestinal Stem Cells and Immune Cell Relationships: Potential Therapeutic Targets for Inflammatory Bowel Diseases.
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肠道干细胞与免疫细胞的关系：炎症性肠病潜在的治疗靶点
DOI：
10.3389/fimmu.2020.623691
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发表时间：
2020
影响因子：
7.3
通讯作者：
Zhang B
中科院分区：
文献类型：
--
作者：
Hou Q;Huang J;Ayansola H;Masatoshi H;Zhang B
哺乳动物的肠道是世界上最大的免疫器官，含有肠道干细胞(ISC)、分化的上皮细胞(肠上皮细胞、潘氏细胞、杯状细胞、簇状细胞等)和肠道驻留免疫细胞(T细胞、B细胞、树突状细胞、先天淋巴样细胞等)。炎症性肠病(IBD)是一种以黏膜损伤和炎症为特征的慢性炎症性疾病，威胁肠道的完整性。损伤后肠粘膜上皮的持续更新和修复依赖于ISCs。炎性黏膜愈合可能成为改善IBD患者临床症状、疾病复发和无切除生存的新靶点。随着体外肠道器官培养和单细胞RNA测序技术的发展，人们对ISC与免疫细胞之间的联系的认识也在不断扩大。最近的研究表明，T细胞、ILCs、树突状细胞和巨噬细胞等免疫细胞以及由这些细胞分泌的细胞因子在ISCs和肠上皮细胞的再生中起关键作用。在炎性黏膜移植ISC可能是重建IBD上皮屏障的一种新的治疗方法。考虑到ISC与免疫细胞之间的联系，我们预测，生物制剂与ISC移植的结合将彻底改变IBD患者未来的治疗方法。
The mammalian intestine is the largest immune organ that contains the intestinal stem cells (ISC), differentiated epithelial cells (enterocytes, Paneth cells, goblet cells, tuft cells, etc.), and gut resident-immune cells (T cells, B cells, dendritic cells, innate lymphoid cell, etc.). Inflammatory bowel disease (IBD), a chronic inflammatory disease characterized by mucosa damage and inflammation, threatens the integrity of the intestine. The continuous renewal and repair of intestinal mucosal epithelium after injury depend on ISCs. Inflamed mucosa healing could be a new target for the improvement of clinical symptoms, disease recurrence, and resection-free survival in IBD treated patients. The knowledge about the connections between ISC and immune cells is expanding with the development of in vitro intestinal organoid culture and single-cell RNA sequencing technology. Recent findings implicate that immune cells such as T cells, ILCs, dendritic cells, and macrophages and cytokines secreted by these cells are critical in the regeneration of ISCs and intestinal epithelium. Transplantation of ISC to the inflamed mucosa may be a new therapeutic approach to reconstruct the epithelial barrier in IBD. Considering the links between ISC and immune cells, we predict that the integration of biological agents and ISC transplantation will revolutionize the future therapy of IBD patients.
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