Association between early respiratory viral infections and structural lung disease in infants with cystic fibrosis.
Association between early respiratory viral infections and structural lung disease in infants with cystic fibrosis.
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DOI：
10.1016/j.jcf.2022.04.014
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发表时间：
2022-11
影响因子：
5.2
通讯作者：
Davis, Stephanie D.
中科院分区：
文献类型：
--
作者：
Sanders, Don B.;Deschamp, Ashley R.;Hatch, Joseph E.;Slaven, James E.;Gebregziabher, Netsanet;Kemner-van de Corput, Mariette;Tiddens, Harm A. W. M.;Rosenow, Tim;Storch, Gregory A.;Hall, Graham L.;Stick, Stephen M.;Ranganathan, Sarath;Ferkol, Thomas W.;Davis, Stephanie D.
患有囊性纤维化（CF）的婴儿在生命早期发展为结构性肺病，病毒感染与进行性肺病相关。我们假设呼吸道病毒的存在与CF婴儿胸部计算机断层扫描（CT）显示的结构性肺部疾病有关。CF婴儿在4个月龄之前入组。在常规访视期间和出现症状时，对鼻拭子进行多重PCR检测，以检测呼吸道病毒。参与者在大约12个月大时接受CT成像。用斯皮尔曼相关系数评估了Perth-Rotterdam注释网格形态定量分析CF（PRAGMA-CF）CT评分与呼吸道病毒和症状之间的相关性。纳入了60名婴儿进行分析。人类鼻病毒是最常见的病毒检测，在28%的测试鼻拭子和85%的参与者。基于PRAGMA-CF的健康肺野范围中位数（IQR）为98.7（0.8）%。PRAGMA-CF与首次感染病毒的年龄或检测到任何病毒（包括鼻病毒、呼吸道合胞病毒或副流感病毒）之间无相关性。气道壁增厚的程度与曾经有喘息（ρ = 0.31，p = 0.02）和咳嗽次数（ρ = 0.25，p = 0.0495）相关。CF婴儿有轻微的结构性肺部疾病。我们没有发现呼吸道病毒和CT异常之间的关联。喘息和咳嗽频率与早期结构变化有关。
Infants with cystic fibrosis (CF) develop structural lung disease early in life, and viral infections are associated with progressive lung disease. We hypothesized that the presence of respiratory viruses would be associated with structural lung disease on computed tomography (CT) of the chest in infants with CF. Infants with CF were enrolled before 4 months of age. Multiplex PCR assays were performed on nasal swabs to detect respiratory viruses during routine visits and when symptomatic. Participants underwent CT imaging at approximately 12 months of age. Associations between Perth–Rotterdam Annotated Grid Morphometric Analysis for CF (PRAGMA-CF) CT scores and respiratory viruses and symptoms were assessed with Spearman correlation coefficients. Sixty infants were included for analysis. Human rhinovirus was the most common virus detected, on 28% of tested nasal swabs and in 85% of participants. The median (IQR) extent of lung fields that was healthy based on PRAGMA-CF was 98.7 (0.8)%. There were no associations between PRAGMA-CF and age at first virus, or detection of any virus, including rhinovirus, respiratory syncytial virus, or parainfluenza. The extent of airway wall thickening was associated with ever having wheezed (ρ = 0.31, p = 0.02) and number of encounters with cough (ρ = 0.25, p = 0.0495). Infants with CF had minimal structural lung disease. We did not find an association between respiratory viruses and CT abnormalities. Wheezing and frequency of cough were associated with early structural changes.
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患有和没有呼吸道症状的儿童的呼吸道病原体。
DOI：
10.1016/j.jpeds.2008.08.036
发表时间：
2009-03
期刊：
The Journal of pediatrics
影响因子：
--
作者：
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通讯作者：
van der Ent CK
影响因子：
8
作者：
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通讯作者：
Naucler, Pontus
影响因子：
3.1
作者：
Schechter, Michael S.;Regelmann, Warren E.;Konstan, Michael W.
通讯作者：
Konstan, Michael W.
影响因子：
5.1
作者：
Stick, Stephen M.;Brennan, Siobhain;Sly, Peter D.
通讯作者：
Sly, Peter D.
DOI：
10.1165/rcmb.2010-0368oc
发表时间：
2011-06-01
影响因子：
6.4
作者：
Sutanto, Erika N.;Kicic, Anthony;Stick, Stephen M.
通讯作者：
Stick, Stephen M.