Effectors of Hyperlipidemia among HIV/AIDS patients with second-line antiretroviral therapy based on register data.
Effectors of Hyperlipidemia among HIV/AIDS patients with second-line antiretroviral therapy based on register data.
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基于登记数据的二线抗逆转录病毒治疗 HIV/AIDS 患者高脂血症的影响因素
DOI：
10.2174/1570162x20666220805103411
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发表时间：
2022-08-05
影响因子：
1
通讯作者：
中科院分区：
文献类型：
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作者：
在这项研究中，我们旨在利用中国中部地区的登记数据，确定接受二线抗逆转录病毒治疗（ART）的HIV/AIDS感染者（PLWHA）中高脂血症的患病率和影响因素。我们进行了一项横断面研究，并从两个医疗登记处收集了2018年期间关于二线抗逆转录病毒治疗的PLWHA信息。根据2016年中国成人血脂异常管理指南对高脂血症进行定义。采用单因素和多因素logistic回归分析探讨高脂血症的影响因素。我们计算了优势比（ORs）和95%置信区间（CIs）。本研究共纳入2886例接受二线ART治疗的PLWHA患者，其中978例（33.9%）患有高脂血症。女性患者、高血糖患者和CD4+细胞计数bbb50 500细胞/μL患者高脂血症患病率较高，分别为37.0%、49.0%和41.3%。多因素分析显示，CD4+细胞计数350 ~ 500个细胞/μL （OR = 1.72, 95% CI: 1.26 ~ 2.38）、CD4+细胞计数>500个细胞/μL （OR = 2.49, 95% CI: 1.85 ~ 3.38）、FPG >6.2 mmol/L （OR = 2.08, 95% CI:1.64 ~ 2.65）是高脂血症的危险因素。男性（OR = 0.72, 95% CI: 0.61-0.85）和Hb <110 g/L （OR = 0.59, 95% CI: 0.45-0.76）是预防高脂血症的保护因素。接受二线抗逆转录病毒治疗的艾滋病患者高脂血症患病率较高。性别、CD4+细胞计数、FPG、血红蛋白是高脂血症的影响因素。
In this study, we aimed to determine the prevalence and effectors of hyperlipidemia among People Living with HIV/AIDS (PLWHA) and taking second-line Antiretroviral Therapy (ART) using registry data in central China. We conducted a cross-sectional study and collected information of PLWHA on second-line ART during 2018 from two medical registries. Hyperlipidemia was defined according to the 2016 Chinese guidelines for the management of dyslipidemia in adults. Univariate and multivariate logistic regression analyses were performed to explore the influencing factors of hyperlipidemia. We calculated Odds Ratios (ORs) and 95% Confidence Intervals (CIs). A total of 2886 PLWHA taking second-line ART were included in this study, and 978 (33.9%) had hyperlipidemia. Female patients, those with hyperglycemia, and patients with CD4+ cell counts >500 cells/μL had a higher prevalence of hyperlipidemia with 37.0%, 49.0%, and 41.3%, respectively. Multivariate analysis showed that CD4+ cell count 350-500 cells/μL (OR = 1.72, 95% CI: 1.26-2.38), CD4+ cell count >500 cells/μL (OR = 2.49, 95% CI: 1.85-3.38), and FPG >6.2 mmol/L (OR = 2.08, 95% CI:1.64-2.65) were risk factors for hyperlipidemia. Male sex (OR = 0.72, 95% CI: 0.61-0.85) and Hb <110 g/L (OR = 0.59, 95% CI: 0.45-0.76) were protective factors against hyperlipidemia. PLWHA on second-line ART had a higher prevalence of hyperlipidemia. Gender, CD4+ cell count, FPG, and hemoglobin were influencing factors of hyperlipidemia.
影响因子：
2.2
作者：
Sinxadi PZ;McIlleron HM;Dave JA;Smith PJ;Levitt NS;Maartens G
通讯作者：
Maartens G