Newly Identified DDT-Related Compounds Accumulating in Southern California Bottlenose Dolphins.
Newly Identified DDT-Related Compounds Accumulating in Southern California Bottlenose Dolphins.
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DOI：
10.1021/acs.est.6b03150
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发表时间：
2016-11-15
影响因子：
11.4
通讯作者：
Hoh E
中科院分区：
文献类型：
--
作者：
Mackintosh SA;Dodder NG;Shaul NJ;Aluwihare LI;Maruya KA;Chivers SJ;Danil K;Weller DW;Hoh E
对生活在南加州海湾的8种常见宽吻海豚(Tursioptruncatus)的鲸脂进行了非靶向GC×GC-TOF/MS分析，以鉴定与DDT相关的新的生物积累化合物，并确定它们相对于通常研究的与DDT相关的化合物的丰度。我们确定了45种生物累积的滴滴涕相关化合物，其中大多数(80%)通常不会在环境介质中进行监测。已鉴定的化合物包括转化产物、工业混合物杂质，如三(氯苯基)甲烷(TCPM)、推定的TCPM代谢物三(氯苯基)-甲醇(TCPMOH)，以及来源不明的结构相关化合物，如六到八氯二苯乙烯。为了调查农药混合物中的杂质作为这些化合物的可能来源，我们分析了该地区历史上主要的污染源--滴滴涕，以及含有滴滴涕相关化合物的当前使用的杀虫剂三氯杀螨醇。这些技术混合物只含有鲸脂中确定的33%的化合物，这表明转化产品贡献了这些海洋健康哨所中与滴滴涕相关的污染物的大部分负荷。定量分析表明，TCPM是鲸脂中含量仅次于DDE的第二大类化合物，且TCPMOH的负荷量大于DDT。QSPR估计证实，4，4‘，4“-TCPM和4，4’，”-TCPMOH具有持久性和生物蓄积性。
Nontargeted GC×GC-TOF/MS analysis of blubber from 8 common bottlenose dolphins (Tursiops truncatus) inhabiting the Southern California Bight was performed to identify novel, bioaccumulative DDT-related compounds and to determine their abundance relative to the commonly studied DDT-related compounds. We identified 45 bioaccumulative DDT-related compounds of which the majority (80%) is not typically monitored in environmental media. Identified compounds include transformation products, technical mixture impurities such as tris(chlorophenyl)methane (TCPM), the presumed TCPM metabolite tris(chlorophenyl)-methanol (TCPMOH), and structurally related compounds with unknown sources, such as hexa- to octachlorinated diphenylethene. To investigate impurities in pesticide mixtures as possible sources of these compounds, we analyzed technical DDT, the primary source of historical contamination in the region, and technical Dicofol, a current use pesticide that contains DDT-related compounds. The technical mixtures contained only 33% of the compounds identified in the blubber, suggesting that transformation products contribute to the majority of the load of DDT-related contaminants in these sentinels of ocean health. Quantitative analysis revealed that TCPM was the second most abundant compound class detected in the blubber, following DDE, and TCPMOH loads were greater than DDT. QSPR estimates verified 4,4′,4″-TCPM and 4,4′4,″-TCPMOH are persistent and bioaccumulative.
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影响因子：
56.9
作者：
ANDERSON, DW;JEHL, JR;EDGECOMB, WG
通讯作者：
EDGECOMB, WG
影响因子：
11.4
作者：
BOETHLING, RS;HOWARD, PH;TIRADO, N
通讯作者：
TIRADO, N
影响因子：
11.4
作者：
BOETHLING, RS;SABLJIC, A
通讯作者：
SABLJIC, A
影响因子：
11.4
作者：
Eganhouse, Robert P.;Pontolillo, James
通讯作者：
Pontolillo, James
DOI：
10.1002/ps.2780420408
发表时间：
1994-12-01
期刊：
PESTICIDE SCIENCE
影响因子：
--
作者：
GILLESPIE, MJ;LYTHGO, CM;WILKINS, JPG
通讯作者：
WILKINS, JPG