Serum globulin and albumin to globulin ratio as potential diagnostic biomarkers for periprosthetic joint infection: a retrospective review.
Serum globulin and albumin to globulin ratio as potential diagnostic biomarkers for periprosthetic joint infection: a retrospective review.
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DOI：
10.1186/s13018-020-01959-1
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发表时间：
2020-10-07
影响因子：
2.6
通讯作者：
Sheng P
中科院分区：
文献类型：
--
作者：
Ye Y;Chen W;Gu M;Xian G;Pan B;Zheng L;Zhang Z;Sheng P
假体周围关节感染（PJI）已越来越多的记录；然而，其术前准确诊断仍然具有挑战性。此外，迫切需要确定适当和有效的生物标志物。我们的目的是评估球蛋白、白蛋白与球蛋白（A/G）比率与翻修全关节置换术（TJA）患者PJI发展之间的关系。回顾性研究了2011年至2018年期间接受改良TJA的患者（89例无菌性机械故障，38例PJI）。采用单因素分析和多因素logistic回归对血清蛋白进行分析。这些蛋白的诊断性能通过受试者工作特征（ROC）曲线进行评估。较高的球蛋白水平（比值比[OR]， 1.239; P < 0.001）和较低的A/G比（OR, 0.007; P < 0.001）与PJI的风险密切相关。ROC曲线分析显示，球蛋白（曲线下面积[AUC] 0.77，敏感性78.95%，特异性69.66%）和A/G比（AUC 0.779，敏感性65.79%，特异性78.65%）具有合理的诊断效果。球蛋白和A/G比值均与PJI相关，可作为PJI诊断的潜在辅助生物标志物。
Periprosthetic joint infection (PJI) has been increasingly documented; however, its preoperative accurate diagnosis remains challenging. Furthermore, there is a dire need to identify appropriate and effective biomarkers. We aimed to evaluate the relationship between globulin, albumin to globulin (A/G) ratio, and development of PJI in patients undergoing revision total joint arthroplasty (TJA). A retrospective study was conducted on patients who had undergone revision TJA between 2011 and 2018 (89 with aseptic mechanic failure and 38 with PJI). The serum proteins were explored using univariate analysis followed by multivariate logistic regression. The diagnostic performance of these proteins was assessed by the receiver operating characteristic (ROC) curve. Higher globulin levels (odds ratio [OR], 1.239; P < 0.001) and lower A/G ratio (OR, 0.007; P < 0.001) were strongly associated with the risk of PJI. ROC curve analysis demonstrated reasonable diagnostic performance for globulin (area under the curve [AUC], 0.77; sensitivity, 78.95%; and specificity, 69.66%) and A/G ratio (AUC, 0.779; sensitivity, 65.79%; and specificity, 78.65%). Both globulin and A/G ratio were associated with PJI and may serve as potential adjuvant biomarkers in the diagnosis of PJI.
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