Osteophyte size and location on hip DXA scans are associated with hip pain: Findings from a cross sectional study in UK Biobank.
Osteophyte size and location on hip DXA scans are associated with hip pain: Findings from a cross sectional study in UK Biobank.
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DOI：
10.1016/j.bone.2021.116146
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发表时间：
2021-12
期刊：
影响因子：
4.1
通讯作者：
Tobias JH
中科院分区：
文献类型：
--
作者：
Faber BG;Ebsim R;Saunders FR;Frysz M;Lindner C;Gregory JS;Aspden RM;Harvey NC;Smith GD;Cootes T;Tobias JH
目前尚不清楚放射学髋关节骨关节炎（rHOA）的不同特征如何导致髋关节疼痛。我们使用一种新的基于双能X线吸收测定法（DXA）的方法研究了rHOA（包括其各个成分）与髋关节疼痛之间的关系。髋关节DXA来自UK Biobank。一种新的自动化方法从股骨头和髋臼周围的点获得最小关节间隙宽度（mJSW）。人工得出髋臼外侧、上级和下级股骨头的骨赘面积。结合骨赘和关节间隙狭窄（JSN）的半定量测量来定义rHOA。通过问卷调查，采用逻辑回归分析这些变量与髋关节疼痛之间的关系。共检查髋关节DXA 6807例。353例（5.2%）患者存在rHOA，与髋关节疼痛[OR 2.42（1.78-3.29）]和医院诊断的OA [6.01（2.98-12.16）]相关。在相互校正的模型中，总骨赘面积（而非mJSW）与髋关节疼痛相关[分别为1.31（1.23-1.39），0.95（0.87-1.04）]。另一方面，JSN作为分类变量显示≥ 1级和≥ 2级JSN与髋关节疼痛之间的相关性较弱[分别为1.30（1.06-1.60），1.80（1.34-2.42）]。髋臼、股骨上级和下部骨赘区域均与髋关节疼痛独立相关[分别为1.13（1.06-1.20）、1.13（1.05-1.24）、1.10（1.03-1.17）]。在该队列中，rHOA和普遍髋关节疼痛之间的关系可以通过二维骨赘面积来解释，但不能通过明显的mJSW来解释。不同位置的骨赘显示出重要的、潜在独立的与髋关节疼痛的相关性，可能反映了不同生物力学途径的贡献。来自DXA图像的放射学髋关节OA与英国生物库中的髋关节疼痛相关。骨赘大小，如DXA图像上骨赘面积所反映的，显示与髋关节疼痛有很强的相关性。相比之下，关节间隙宽度与髋关节疼痛仅弱相关。
It remains unclear how the different features of radiographic hip osteoarthritis (rHOA) contribute to hip pain. We examined the relationship between rHOA, including its individual components, and hip pain using a novel dual-energy x-ray absorptiometry (DXA)-based method. Hip DXAs were obtained from UK Biobank. A novel automated method obtained minimum joint space width (mJSW) from points placed around the femoral head and acetabulum. Osteophyte areas at the lateral acetabulum, superior and inferior femoral head were derived manually. Semi-quantitative measures of osteophytes and joint space narrowing (JSN) were combined to define rHOA. Logistic regression was used to examine the relationships between these variables and hip pain, obtained via questionnaires. 6807 hip DXAs were examined. rHOA was present in 353 (5.2%) individuals and was associated with hip pain [OR 2.42 (1.78–3.29)] and hospital diagnosed OA [6.01 (2.98–12.16)]. Total osteophyte area but not mJSW was associated with hip pain in mutually adjusted models [1.31 (1.23–1.39), 0.95 (0.87–1.04) respectively]. On the other hand, JSN as a categorical variable showed weak associations between grade ≥ 1 and grade ≥ 2 JSN with hip pain [1.30 (1.06–1.60), 1.80 (1.34–2.42) respectively]. Acetabular, superior and inferior femoral osteophyte areas were all independently associated with hip pain [1.13 (1.06–1.20), 1.13 (1.05–1.24), 1.10 (1.03–1.17) respectively]. In this cohort, the relationship between rHOA and prevalent hip pain was explained by 2-dimensional osteophyte area, but not by the apparent mJSW. Osteophytes at different locations showed important, potentially independent, associations with hip pain, possibly reflecting the contribution of distinct biomechanical pathways. Radiographic hip OA, derived from DXA images, is associated with hip pain in UK Biobank. Osteophyte size, as reflected by osteophyte area on the DXA image, shows strong associations with hip pain. In contrast, joint space width is only weakly associated with hip pain.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
7
作者：
Hartley, A.;Hardcastle, S. A.;Gregson, C. L.
通讯作者：
Gregson, C. L.
影响因子：
2.3
作者：
Bedson, John;Croft, Peter R.
通讯作者：
Croft, Peter R.
DOI：
10.1097/01.blo.0000096804.78689.c2
发表时间：
2003-12-01
影响因子：
4.2
作者：
Ganz, R;Parvizi, J;Siebenrock, KA
通讯作者：
Siebenrock, KA
影响因子：
2.3
作者：
Hunter, David J.;McDougall, Jason J.;Keefe, Francis J.
通讯作者：
Keefe, Francis J.