Local Variation in Recombination Rates of the Honey Bee (Apis mellifera) Genome among Samples from Six Disparate Populations.
Local Variation in Recombination Rates of the Honey Bee (Apis mellifera) Genome among Samples from Six Disparate Populations.
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DOI：
10.1007/s00040-019-00736-6
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发表时间：
2020-02
期刊：
影响因子：
1.3
通讯作者：
Rueppell O
中科院分区：
文献类型：
--
作者：
DeLory T;Funderburk K;Miller K;Smith WZ;McPherson S;Pirk CW;Costa C;Teixeira ÉW;Dahle B;Rueppell O
减数分裂重组是真核生物有性生殖的重要组成部分，但其发生频率在基因组内和基因组间各不相同。虽然已经确定蜜蜂具有约20 cM/Mbp的高重组率，但对这种异常率的近因和最终原因知之甚少。在这里，我们描述了六个连锁图谱的西方蜜蜂蜜蜂，产生了一致的方法，从不同的部分物种的近全球分布的样本。我们比较了这六个图谱的全基因组比率和减数分裂交换的分布，发现了相当大的差异。我们的样本之间的局部重组率的总体相似性是无关的地理或我们的样本来自种群的系统发育距离。然而，有限的采样限制了我们对结果的解释，因为目前还不清楚这些样本的代表性如何。与以往的研究相比，我们发现只有在两个数据集的本地重组率和GC含量之间的显着关系。专注于特定地图中特别增加或减少重组的区域，我们在这些区域中确定了几个丰富的基因本体，并推测它们的局部适应性相关性。这些数据有助于越来越多的比较努力，以了解重组率的种内变异及其在蜜蜂和其他社会昆虫中的进化作用。
Meiotic recombination is an essential component of eukaryotic sexual reproduction but its frequency varies within and between genomes. Although it is well-established that honey bees have a high recombination rate with about 20 cM/Mbp, the proximate and ultimate causes of this exceptional rate are poorly understood. Here, we describe six linkage maps of the Western Honey Bee Apis mellifera that were produced with consistent methodology from samples from distinct parts of the species’ near global distribution. We compared the genome-wide rates and distribution of meiotic crossovers among the six maps and found considerable differences. Overall similarity of local recombination rates among our samples was unrelated to geographic or phylogenetic distance of the populations that our samples were derived from. However, the limited sampling constrains the interpretation of our results because it is unclear how representative these samples are. In contrast to previous studies, we found only in two datasets a significant relation between local recombination rate and GC content. Focusing on regions of particularly increased or decreased recombination in specific maps, we identified several enriched gene ontologies in these regions and speculate about their local adaptive relevance. These data are contributing to an increasing comparative effort to gain an understanding of the intra-specific variability of recombination rates and their evolutionary role in honey bees and other social insects.
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影响因子：
3.8
作者：
CHARLESWORTH, B;CHARLESWORTH, D
通讯作者：
CHARLESWORTH, D
影响因子：
7
作者：
Beye, Martin;Gattermeier, Irene;Page, Robert E., Jr.
通讯作者：
Page, Robert E., Jr.
影响因子：
4.5
作者：
Comeron JM;Ratnappan R;Bailin S
通讯作者：
Bailin S
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
4.6
作者：
Alleman, Austin;Feldmeyer, Barbara;Foitzik, Susanne
通讯作者：
Foitzik, Susanne