Relationship between amyloid and tau levels and its impact on tau spreading.
Relationship between amyloid and tau levels and its impact on tau spreading.
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DOI：
10.1007/s00259-021-05191-9
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发表时间：
2021-07
影响因子：
9.1
通讯作者：
Rowe CC
中科院分区：
文献类型：
--
作者：
Doré V;Krishnadas N;Bourgeat P;Huang K;Li S;Burnham S;Masters CL;Fripp J;Villemagne VL;Rowe CC
Previous studies have shown that Aβ-amyloid (Aβ) likely promotes tau to spread beyond the medial temporal lobe. However, the Aβ levels necessary for tau to spread in the neocortex is still unclear. Four hundred sixty-six participants underwent tau imaging with [18F]MK6420 and Aβ imaging with [18F]NAV4694. Aβ scans were quantified on the Centiloid (CL) scale with a cut-off of 25 CL for abnormal levels of Aβ (A+). Tau scans were quantified in three regions of interest (ROI) (mesial temporal (Me); temporoparietal neocortex (Te); and rest of neocortex (R)) and four mesial temporal region (entorhinal cortex, amygdala, hippocampus, and parahippocampus). Regional tau thresholds were established as the 95%ile of the cognitively unimpaired A- subjects. The prevalence of abnormal tau levels (T+) along the Centiloid continuum was determined. The plots of prevalence of T+ show earlier and greater increase along the Centiloid continuum in the medial temporal area compared to neocortex. Prevalence of T+ was low but associated with Aβ level between 10 and 40 CL reaching 23% in Me, 15% in Te, and 11% in R. Between 40 and 70 CL, the prevalence of T+ subjects per CL increased fourfold faster and at 70 CL was 64% in Me, 51% in Te, and 37% in R. In cognitively unimpaired, there were no T+ in R below 50 CL. The highest prevalence of T+ were found in the entorhinal cortex, reaching 40% at 40 CL and 80% at 60 CL. Outside the entorhinal cortex, abnormal levels of cortical tau on PET are rarely found with Aβ below 40 CL. Above 40 CL prevalence of T+ accelerates in all areas. Moderate Aβ levels are required before abnormal neocortical tau becomes detectable. The online version contains supplementary material available at 10.1007/s00259-021-05191-9.
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DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
4.2
作者：
Lopresti, Brian J.;Campbell, Elizabeth M.;Tudorascu, Dana L.
通讯作者：
Tudorascu, Dana L.
影响因子：
11.1
作者：
Petersen RC;Caracciolo B;Brayne C;Gauthier S;Jelic V;Fratiglioni L
通讯作者：
Fratiglioni L
影响因子：
11.2
作者：
Klunk, WE;Engler, H;Långström, B
通讯作者：
Långström, B
影响因子：
5.7
作者：
Bourgeat, Pierrick;Dore, Vincent;Rowe, Christopher C.
通讯作者：
Rowe, Christopher C.