A fast computational model for circulatory dynamics: effects of left ventricle-aorta coupling.
A fast computational model for circulatory dynamics: effects of left ventricle-aorta coupling.
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DOI：
10.1007/s10237-023-01690-w
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发表时间：
2023-06
影响因子：
3.5
通讯作者：
Secomb, Timothy W. W.
中科院分区：
文献类型：
--
作者：
Moulton, Michael J. J.;Secomb, Timothy W. W.
关键词：
诸如高血压、收缩性心力衰竭和射血分数保留的心力衰竭等疾病的病程受到左心室（LV）和脉管系统之间的相互作用的影响。为了研究这些相互作用，提出了一个计算效率高，基于生物药理学的循环系统数学模型。在心脏的四腔室模型中，LV由先前描述的低阶壁体积保持模型表示，该模型包括扭转和基部到顶点以及周向壁缩短和延长，并且其他腔室使用球形几何形状表示。包括所有四个腔室的主动和被动心肌力学。心脏模型与主动脉的波传播模型和闭合集总参数循环模型耦合。通过拟合实验数据确定正常心脏和主动脉的参数。主动脉反射脉搏波的时间和幅度的变化与主动脉顺应性和锥度的变化（如老化中所见）（顺应性降低，直径和长度增加）有关，并预测了对LV压力-容积环和LV纤维应力和肌节缩短的影响。检查主动脉老化和LV收缩力降低（心力衰竭）的影响。在衰竭的心脏中，随着年龄的增长，主动脉特性的变化影响每搏输出量和肌节缩短，而主动脉压没有明显增加，反射的压力波有助于增加主动脉压的比例。在线版本包含补充材料，可通过10.1007/s10237-023-01690-w获得。
The course of diseases such as hypertension, systolic heart failure and heart failure with a preserved ejection fraction is affected by interactions between the left ventricle (LV) and the vasculature. To study these interactions, a computationally efficient, biophysically based mathematical model for the circulatory system is presented. In a four-chamber model of the heart, the LV is represented by a previously described low-order, wall volume-preserving model that includes torsion and base-to-apex and circumferential wall shortening and lengthening, and the other chambers are represented using spherical geometries. Active and passive myocardial mechanics of all four chambers are included. The cardiac model is coupled with a wave propagation model for the aorta and a closed lumped-parameter circulation model. Parameters for the normal heart and aorta are determined by fitting to experimental data. Changes in the timing and magnitude of pulse wave reflections by the aorta are demonstrated with changes in compliance and taper of the aorta as seen in aging (decreased compliance, increased diameter and length), and resulting effects on LV pressure–volume loops and LV fiber stress and sarcomere shortening are predicted. Effects of aging of the aorta combined with reduced LV contractile force (failing heart) are examined. In the failing heart, changes in aortic properties with aging affect stroke volume and sarcomere shortening without appreciable augmentation of aortic pressure, and the reflected pressure wave contributes an increased proportion of aortic pressure. The online version contains supplementary material available at 10.1007/s10237-023-01690-w.
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影响因子：
2.4
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