Risk of Cancer in Children Conceived by Assisted Reproductive Technology.
Risk of Cancer in Children Conceived by Assisted Reproductive Technology.
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DOI：
10.1542/peds.2015-2061
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发表时间：
2016-03
期刊：
影响因子：
8
通讯作者：
Storeng R
中科院分区：
文献类型：
--
作者：
Reigstad MM;Larsen IK;Myklebust TÅ;Robsahm TE;Oldereid NB;Brinton LA;Storeng R
越来越多的儿童是在辅助生殖技术(ART)后出生的，监测其长期健康影响是令人感兴趣的。这项研究比较了接受抗逆转录病毒治疗和非抗逆转录病毒治疗的儿童患癌症的风险。挪威医学出生登记处(MBRN)包含关于在挪威出生的所有儿童的个人信息(包括ART受孕信息)。所有在1984至2011年间出生的儿童构成了研究队列，癌症数据从挪威癌症登记处(CRN)获得。随访从出生之日开始，到第一次被诊断为癌症、死亡、移民或2011年12月31日结束。用Cox比例风险模型计算ART妊娠与非ART妊娠儿童总体癌症风险的风险比(HR)和95%可信区间(CI)。所有儿童癌症类型的癌症风险也分别进行了评估。研究队列包括1 628 658名儿童，其中25 782名是通过ART受孕的。在总共4554例癌症中，51例发生在ART受孕的儿童中。总体癌症风险并未显著增加，HR为1.21(95%CI为0.90-1.63)。然而，与非ART怀孕的儿童相比，ART怀孕的儿童患白血病的风险增加，HR为1.67(95%CI为1.02-2.73)。基于较小的数字，发现ART妊娠的儿童患霍奇金淋巴瘤的风险增加，HR为3.63(95%CI为1.12-11.72)。这项基于人群的队列研究发现，ART怀孕的儿童患白血病和霍奇金淋巴瘤的风险增加。
An increasing number of children are born after assisted reproductive technology (ART) and monitoring their long-term health effects is of interest. This study compares cancer risk in children conceived by ART to that in children conceived without. The Medical Birth Registry of Norway (MBRN) contains individual information on all children born in Norway (including information of ART conceptions). All children born between 1984 and 2011 constituted the study cohort, and cancer data were obtained from the Cancer Registry of Norway (CRN). Follow-up started at date of birth, and ended on the date of the first cancer diagnosis, death, emigration, or 31st December 2011. A Cox proportional hazards model was used to calculate hazard ratios (HR) and 95% confidence intervals (CI) of overall cancer risk between children conceived by ART and those not. Cancer risk was also assessed separately for all childhood cancer types. The study cohort comprised 1 628 658 children, of which 25 782 were conceived by ART. Of the total 4554 cancers, 51 occurred in ART conceived children. Risk of overall cancer was not significantly elevated, HR 1.21 (95% CI 0.90–1.63). However, increased risk of leukemia was observed for children conceived by ART compared to those who were not, HR 1.67 (95% CI 1.02–2.73). Based on small numbers, an elevated risk of Hodgkin lymphoma was found for ART conceived children, HR 3.63 (95% CI 1.12–11.72). This population-based cohort study found elevated risks of leukemia and Hodgkin lymphoma in children conceived by ART.
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影响因子：
8
作者：
Bjorge, Tone;Sorensen, Henrik Toft;Troisi, Rebecca
通讯作者：
Troisi, Rebecca
影响因子：
6.4
作者：
Hargreave, Marie;Jensen, Allan;Deltour, Isabelle;Brinton, Louise A.;Andersen, Klaus K.;Kjaer, Susanne K.
通讯作者：
Kjaer, Susanne K.
影响因子：
6.1
作者：
Ericson, A;Nygren, KG;Källén, B
通讯作者：
Källén, B
影响因子：
11.2
作者：
Crump, Casey;Sundquist, Jan;Sundquist, Kristina
通讯作者：
Sundquist, Kristina
影响因子：
5.1
作者：
DeBaun, MR;Tucker, MA
通讯作者：
Tucker, MA