Increased risk for cancer among offspring of women with fertility problems.
Increased risk for cancer among offspring of women with fertility problems.
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DOI：
10.1002/ijc.28110
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发表时间：
2013-09-01
影响因子：
6.4
通讯作者：
Kjaer, Susanne K.
中科院分区：
文献类型：
--
作者：
Hargreave, Marie;Jensen, Allan;Deltour, Isabelle;Brinton, Louise A.;Andersen, Klaus K.;Kjaer, Susanne K.
一些研究表明，生育治疗后出生的孩子有患癌症的潜在风险，但结果不一致。此外，生育治疗的任何负面影响可能是由于潜在的不孕症，而不是程序本身。在迄今为止最大的生育信息队列研究中，我们检查了有生育问题的女性的后代是否比没有生育问题的女性的后代患癌症的风险更高。该研究队列包括1964年至2006年在丹麦出生的2830054名后代。其中，125 844名是接受不孕症评估的妇女的后代。考克斯回归模型被用来评估作为不孕症妇女的后代对癌症风险的可能影响。分别对儿童期（0-19岁）癌症和青年期（≥ 20岁）癌症进行分析。我们发现，有生育问题的女性所生的后代在儿童时期（风险比（HR），1.18; 95%置信区间（CI），1.05-1.32）和青年期（HR，1.22; 95% CI，1.04-1.43）患癌症的总体风险高于没有生育问题的女性的后代。有生育问题的妇女的后代在儿童时期患白血病的风险显著增加（HR，1.30; 95%CI，1.06-1.60），在年轻的成年期患内分泌腺癌的风险显著增加（HR，2.67; 95%CI，1.35-5.29）。这些发现表明，有生育问题的母亲所生的后代在童年和青年时期患癌症的风险增加。如果这是真实的，我们的研究结果表明，儿童期癌症风险总体增加18%，青年期癌症风险总体增加22%，这意味着每10万名暴露后代中约有4例儿童癌症病例和9例青年癌症病例。
Some studies have indicated that children born after fertility treatment have a potential risk for cancer, but the results are inconsistent. Furthermore, any negative effects of fertility treatment might be due to the underlying infertility rather than to the procedure itself. In the largest cohort study to date with information on fertility, we examined whether the offspring of women with fertility problems had a higher risk for cancer than offspring of women without fertility problems. The study cohort consisted of 2 830 054 offspring born in Denmark between 1964 and 2006. Of these, 125 844 were offspring of women evaluated for infertility. Cox regression models were used to estimate the possible effect of being the offspring of a woman evaluated for infertility on the risk for cancer. Analyses were performed separately for cancer during childhood (0–19 years) and cancer in young adulthood (≥ 20 years). We found that offspring born to women with fertility problems had higher overall risks for cancer in childhood (hazard ratio (HR), 1.18; 95% confidence interval (CI), 1.05–1.32) and in young adulthood (HR, 1.22; 95% CI, 1.04–1.43) than offspring of women without fertility problems. Offspring of women with fertility problems had significantly increased risks for leukemia in childhood (HR, 1.30; 95% CI, 1.06–1.60) and for cancer of the endocrine glands in young adulthood (HR, 2.67; 95% CI, 1.35–5.29). These findings suggest that offspring born to mothers with fertility problems are at increased risk for cancer in both childhood and young adulthood. If real, our findings of an ∼18% overall increase in risk for cancer in childhood and an ∼22% overall increase in risk for cancer in young adulthood would mean about four additional cases of childhood cancer and about nine additional cases of cancer in young adults per 100 000 exposed offspring.
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影响因子：
6.1
作者：
Marees, T.;Dommering, C. J.;Moll, A. C.
通讯作者：
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影响因子：
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通讯作者：
Gjerstorff, Marianne Lundkjaer
影响因子：
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作者：
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通讯作者：
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