Strategies for Improving Peptide Stability and Delivery.
Strategies for Improving Peptide Stability and Delivery.
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DOI：
10.3390/ph15101283
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发表时间：
2022-10-19
期刊：
影响因子：
--
通讯作者：
Albericio F
中科院分区：
文献类型：
--
作者：
Al Musaimi O;Lombardi L;Williams DR;Albericio F
肽由于其高度特异性和积极的安全性，在许多领域发挥着重要作用，包括免疫学，医学诊断和药物发现。然而，对于它们作为活性药物成分、递送载体或诊断成像分子的递送，它们遭受两个严重的缺点：它们差的代谢稳定性和短的半衰期。正在投入大量研究努力来解决这些缺点，其中已经开发了结构修饰和新的递送策略，以提高它们作为功能齐全的物种达到目标的能力。选择的技术，以提高对酶降解途径的肽的抗性和最大限度地提高其治疗效果的好处也进行了审查。特别注意的细胞穿透肽作为传递载体，以及钉合修饰的肽，这已证明从其亲本肽的上级稳定性，报告。
Peptides play an important role in many fields, including immunology, medical diagnostics, and drug discovery, due to their high specificity and positive safety profile. However, for their delivery as active pharmaceutical ingredients, delivery vectors, or diagnostic imaging molecules, they suffer from two serious shortcomings: their poor metabolic stability and short half-life. Major research efforts are being invested to tackle those drawbacks, where structural modifications and novel delivery tactics have been developed to boost their ability to reach their targets as fully functional species. The benefit of selected technologies for enhancing the resistance of peptides against enzymatic degradation pathways and maximizing their therapeutic impact are also reviewed. Special note of cell-penetrating peptides as delivery vectors, as well as stapled modified peptides, which have demonstrated superior stability from their parent peptides, are reported.
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影响因子：
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作者：
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影响因子：
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